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An ultrastructural and functional assessment of nasal cilia and spermatozoa in an infertile human male and healthy controls


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Harlow, LD and Watkins, WB and Koutoulis, A (2004) An ultrastructural and functional assessment of nasal cilia and spermatozoa in an infertile human male and healthy controls. Papers and Proceedings of the Royal Society of Tasmania, 138. pp. 1-10. ISSN 0080-4703

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Ciliary disorders are complex and enigmatic, and can lead to and complications. Human males who produce spermatozoa
with defective flagella may also possess defective cilia. In this the motility and ultrastructure ofnasal cilia/cells and spermatozoa
of an infertile Tasmanian male patient were examined in order to elucidate the cause of his infertility. A detailed examination of the variation
in cilia and spermatozoa of control subjects was also conducted. The axonemal structure of all nasal samples from control subjects
showed a low frequency of abnormalities; however, when present, abnormalities varied between samples. The nasal cells and spermatozoa
of the infertile patient were distinct from control samples, both in terms of motility and ultrastructure. The spermatozoa axonemes of
the patient displayed the normal 9+2 microtubule ultrastructure; however, the proportion of immotile spermatozoa and ultrastructural
abnormalities was higher than in control samples. All of the patient's nasal cilia were functionally immotile and approximately 70% of
ciliated cells displayed extensive ciliary fusion; a feature not found in controls and not previously described. Despite having immotile nasal
cilia, this patient was healthy with no obvious respiratory ailments. Additionally, the nasal cells of the patient possessed mitochondria with
distended membranes, internalised membranous material, cilia with vesicles and internalised axonemes. These features suggest that ciliary
deployment and membrane deposition was compromised in the patient.

Item Type: Article
Keywords: Royal Society of Tasmania, RST, Van Diemens Land, natural history, science, ecology, taxonomy, botany, zoology, geology, geography, papers & proceedings, Australia, UTAS Library
Journal or Publication Title: Papers and Proceedings of the Royal Society of Tasmania
Page Range: pp. 1-10
ISSN: 0080-4703
Collections: Royal Society Collection > Papers & Proceedings of the Royal Society of Tasmania
Additional Information:

Copyright Royal Society of Tasmania

Date Deposited: 18 May 2012 02:05
Last Modified: 15 Sep 2017 01:06
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