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The availability of organic nitrates from intravenous administration systems


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Cossum, Paul Adrian 1981 , 'The availability of organic nitrates from intravenous administration systems', Unspecified thesis, University of Tasmania.

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Nitroglycerin and isosorbide dinitrate are two drugs which
are infused intravenously during the treatment of ischaemic
heart disease. The availability of these two drugs in
solutions infused from plastic infusion bags or glass
infusion bottles through plastic giving sets has been
During simulated infusions the concentration of nitroglycerin
and isosorbide dinitrate appearing in the effluent of the
giving set tubing was found to be much less than the
concentration of the drug solution initially contained in the
plastic infusion bag or glass infusion bottle. It was found
that each component of the plastic infusion equipment sorbed
the drugs to a significant extent and that the rate of
disappearance of drugs from solutions stored in each
component was in the rank order: giving set tubing > giving
set burette > plastic infusion bag. There was no significant
loss of either drug from solutions stored in glass bottles.
The influence of formulation factors and storage conditions
on the sorption of nitroglycerin, isosorbide dinitrate and
another organic nitrate compound, ethylene glycol dinitrate,
by plastic infusion equipment was studied. The extent of
loss during simulated infusions was also found to be
dependent on flow rate of drug solution through the giving
set. The sorption of nitroglycerin and isosorbide dinitrate has
clinical and pharmacokinetic significance.
Losses of nitroglycerin and isosorbide dinitrate associated
with their infusion through plastic Lnfusion equipment were
minimised by infusing drug solutions from a glass syringe
through high density polyethylene tubing. This method was
also successfully applied to overcome the previously reported
loss of diazepam and chlormethiazole during infusions using
conventional plastic administration equipment.

Item Type: Thesis - Unspecified
Authors/Creators:Cossum, Paul Adrian
Keywords: Intravenous therapy, Nitroglycerin, Isosorbide dinitrate
Copyright Holders: The Author
Copyright Information:

Copyright 1981 the Author - The University is continuing to endeavour to trace the copyright
owner(s) and in the meantime this item has been reproduced here in good faith. We
would be pleased to hear from the copyright owner(s).

Additional Information:

Thesis (M.Pharm.)--University of Tasmania, 1981. Bibliography: l. 82-111

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