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The metabolism of bromine in mammals.


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Barta, Joseph 1966 , 'The metabolism of bromine in mammals.', Unspecified thesis, University of Tasmania.

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The aim of the present investigation was to determine whether
bromine has a physiological role in the mammalian body.
For this purpose the following investigations were carried out:
(1) Bromide levels and its possible binding to protein in the sera of
human subjects and guinea pigs were examined. No protein bound bromine
was found in either. The bromide ratios of red blood cells to serum and
of the serum to C.S.F. were determined. The concentration varies
between cells and serum in blood, but only to a limited extent, and is
higher than in C.S.F. The blood concentration is influenced by diet.
The bromide/chloride ratio in both serum and C.S.F. were also measured
and was found to be different. The serum bromide levels in a group of schizophrenic patients
fell within the lower half of the normal range. This was shown to be
due to the dietary factor.
(2) The bromide content in various tissues of man (including various
regions of one human brain), of guinea pigs, of rabbits and of rats were
examined by a chemical method. A radio-isotope method was also used
but only in guinea pigs. The results showed that no tissue concentrates
bromide preferentially, with the exception of the stomach (measured only
in guinea pigs). No protein bound bromine was found in the pituitary.
The prolonged administration of varying amounts of bromide to
guinea pigs showed that there was a progressive accumulation of bromide
in all organs studied, the highest being in the serum.
The addition of fluoride to the drinking water of guinea pigs
significantly decreased the bromide level in all tissues studied. This suggests that fluoride can displace bromide in tissues.
(3) The effect of bromide and fluoride on thyroid. function was
investigated, and the results suggest that bromide may stimulate and
fluoride depress the production of thyroid hormone.
(4-) The rate of bromide excretion in humans was investigated using both
radioisotopic and chemical techniques; the results showed that there was
very little excretion during the first 24 hours (approximately 2 percent) and
that the average biological half-life of bromide is approximately 6 days.
Studies also indicated that chloride is excreted. preferentially to
bromide by the kidney. It was found that bromide is excreted. at a
reduced rate during the night. This diurnal rhythm of bromide
excretion follows very closely that of chloride and sodium. There was
no definite relationship between urinary volume and bromide excretion.
(5) Prolonged administration of bromide and. fluoride to guinea pigs
showed no significant effect on blood components, such as sodium,
potassium, acetyl cholinesterase and alanine amino transferase (G.P.T).

Item Type: Thesis - Unspecified
Authors/Creators:Barta, Joseph
Keywords: Bromine metabolism, Mammals
Copyright Holders: The Author
Copyright Information:

Copyright 1966 the Author - The University is continuing to endeavour to trace the copyright
owner(s) and in the meantime this item has been reproduced here in good faith. We
would be pleased to hear from the copyright owner(s).

Additional Information:

Thesis (M.Sc.) - University of Tasmania, 1967. Includes bibliography

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