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The development of a new tracheal stenosis model in piglets and its repair with a free periosteal graft


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Cohen, Ralph C(Ralph Clinton) 1988 , 'The development of a new tracheal stenosis model in piglets and its repair with a free periosteal graft', Unspecified thesis, University of Tasmania.

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Airway narrowing in-children from congenital
stenosis or acquired stricture remains a difficult
and challenging surgical problem. When the segment
of tracheal stenosis is short, the best surgical
treatment is to excise the stenosis and perform a
primary end-to-end anastomosis. When there is an
extensive segment of tracheal stenosis, this is
clearly not possible and another means of enlarging
the airway has to be devised. An appealing
technique is to incise the stenotic segment
longitudinally throughout its length, insert an
endotracheal stent and then repair the resultant
defect in the trachea with a suitable graft
In this series of experiments, this technique
is.examined in the thoracic segment of the piglet
trachea. The study is performed in two phases.
The initial experiments involve the normal trachea
in which a, window defect is created over the entire
length of the thoracic trachea involving 30% of its
circumference. This defect represents that which
would result when a stenotic segment of trachea is
incised longitudinally. The window defect is then
repaired with a free tibial periosteal graft. In
the second phase, a model of tracheal stenosis is
created by encircling the thoracic trachea with a
silastic sheet. Once respiratory distress is
established, the silastic sheet is removed at a
second operation, and the stenotic segment incised, an endotracheal silastic stent inserted through the
defect and the defect repaired with free
tibial periosteal graft. The pigs are sacrified
three months later when they have grown to about
six times their original weight and the trachea
removed. These studies demonstrate that free
tibial periosteal grafts are an ideal biological
material for repairing tracheal defects. The
periosteum forms bone in a short period of time and
supports the airway; the lumenal surface is lined
with columnar and respiratory epithelium.
This model suggests that tracheal stenosis in
children may be surgically corrected by simply
incising the stenotic segment longitudinally and
enlarging the tracheal diameter by inserting a free
periosteal graft into the defect.

Item Type: Thesis - Unspecified
Authors/Creators:Cohen, Ralph C(Ralph Clinton)
Keywords: Trachea, Trachea
Copyright Holders: The Author
Copyright Information:

Copyright 1998 the Author - The University is continuing to endeavour to trace the copyright
owner(s) and in the meantime this item has been reproduced here in good faith. We
would be pleased to hear from the copyright owner(s).

Additional Information:

Thesis (M.S.)--University of Tasmania, 1988. Bibliography: p. 41-45

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