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The effect of autologous tumour vaccine on benzo-a-pyrene induced squamous cell carcinoma of skin in mice


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Al-lahham, Y 1997 , 'The effect of autologous tumour vaccine on benzo-a-pyrene induced squamous cell carcinoma of skin in mice', Coursework Master thesis, University of Tasmania.

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Many studies have correlated the presence of infiltrating immune cells
within solid tumours, with a more favourable prognosis. These observations
indicate that the immune system may act to defend against tumour formation or
growth. The generation of an immune response requires that the tumour cells
express antigens recognised by the host immune system. The association between
an impaired immune system with advanced tumours and poor prognosis suggests
that appropriate stimulation of the immune system against tumour tissues might
be beneficial.
Active specific immunotherapy with autologous tumour cells or extract
has been shown to be effective in causing regression of tumour. The prerequisite
for effective immunotherapy is the expression of structures on tumour cells
which are antigenic to the immune system and may function as rejection antigens.
Various attempts have been made to identify such antigens in different tumours.
Many antigens have been detected in different tumours, some of these antigens
are immunogenic and some are not.
In an attempt to overcoming the difficulty in identifying the tumour
antigens and in determining which are immunogenic, could be used as an
indicator of the immunogenicity of tumour cells. DC are an antigen presenting cells, the presence of these cells in the region of tumour tissues may indicate the
presence of an immunogenic antigens on tumour cells. In this study, squamous
tumours induced by BP were chosen for immunotherapy by autologous tumour
vaccine because these tumours were reported to have high numbers of dendritic.
The application of tumour vaccine to mice possessing these tumours was shown
to be effective and to lead to an enhanced immune response against tumour cells
compared to controls. DC infiltration of tumours in test group was significantly
higher than DC infiltration of control group, this correlating with high degree of
tumour necrosis and infiltration of tumours by non-DC leukocytes in test group
compared to the control group.

Item Type: Thesis - Coursework Master
Authors/Creators:Al-lahham, Y
Keywords: Skin, Cancer
Copyright Holders: The Author
Copyright Information:

Copyright 1997 the Author - The University is continuing to endeavour to trace the copyright
owner(s) and in the meantime this item has been reproduced here in good faith. We
would be pleased to hear from the copyright owner(s).

Additional Information:

Thesis (M.Med.Sc.)--University of Tasmania, 1998. Includes bibliographical references

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