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Cutaneous tolerance induction : a possible strategy for the treatment of autoimmune disease


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Chen, Yi-Peng 1998 , 'Cutaneous tolerance induction : a possible strategy for the treatment of autoimmune disease', PhD thesis, University of Tasmania.

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Exposure of murine skin to carcinogens such as 7,12-
dimethylbenz[a]anthracene (DMBA) or ultraviolet light B (UVB) irradiation
depletes the epidermal Langerhans cells (LC) and alters the local
environment such that antigen applied through the treated skin causes the
development of antigen specific immunosuppression. This ability to induce
suppression was used as a strategy to downregulate an established immune
response in mice sensitised to a contact sensitiser or mice with autoimmune
Mice immune to picryl chloride or 2,4,6-trinitrochlorobenzene (TNCB) were
treated with either DMBA or UVB irradiation which was then followed by
TNCB through the treated skin. The DMBA followed by TNCB treatment
downregulated both contact hypersensitivity (CHS) and antibody production
in an antigen specific manner, whereas UVB followed by TNCB treatment
could only downregulate the CHS response. When spleen cells were
transferred from TNCB tolerant mice (i.e. naive mice treated with DMBA
followed by TNCB) to TNCB-immune mice, both an established CHS and an
established antibody response were downregulated in an antigen specific
manner. Although there was significant downregulation, the reduction was
not complete as it did not reach the background level.

Item Type: Thesis - PhD
Authors/Creators:Chen, Yi-Peng
Keywords: Autoimmune diseases
Copyright Holders: The Author
Copyright Information:

Copyright 1998 the Author – The University is continuing to endeavour to trace the copyright owner(s) and in the meantime this item has been reproduced here in good faith. We would be pleased to hear from the copyright owner(s).

Additional Information:

Contents: 1. Downregulation of established immune response by chemical carcinogen -- 2. Downregulation of established immune response by physical carcinogen -- 3. Peripheral tolerance induction in thymectomised mice by immunisation through chemical carcinogen altered skin. Thesis (Ph.D.)--University of Tasmania, 1998. Includes bibliographical references

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