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Abstract

The constant-flow perfused rat hindlimb was used as a model to characterize norepinephrine (NE, noradrenaline)- and serotonin (5-HT)-mediated vasoconstriction and their associated effects on metabolism. Rat hindlimbs of various sizes were perfused using medium with or without erythrocytes at temperatures varying between 25 and 37°C. Varying these perfusion parameters altered the quantitative, but not qualitative, effects of the hormones.
In the hindlimb, infusion of NE stimulated both a1- and b-adrenoceptors (AR). The overall effect was the rapid onset of a sustained increase in perfusion pressure which was only slightly increased upon b-AR blockade. Energy for NE-stimulated vasoconstriction was supplied via aerobic means, involving oxidative formation of ATP. In addition, vasoconstriction appeared to be dependent on extracellular Ca2+, suggesting an a1A-AR-stimulated Ca2+ influx through plasma membrane channels.

Item Type:	Thesis - PhD
Authors/Creators:	Dora, Kim A(Andrea)
Keywords:	Hindlimb, Metabolism
Copyright Holders:	The Author
Copyright Information:	Copyright 1993 the Author - The University is continuing to endeavour to trace the copyright owner(s) and in the meantime this item has been reproduced here in good faith. We would be pleased to hear from the copyright owner(s).
Additional Information:	Includes bibliographical references. Thesis (Ph.D.)--University of Tasmania, 1994
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