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Characterization of the vascular control of hindlimb metabolism


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Dora, Kim A(Andrea) 1993 , 'Characterization of the vascular control of hindlimb metabolism', PhD thesis, University of Tasmania.

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The constant-flow perfused rat hindlimb was used as a model to characterize norepinephrine (NE, noradrenaline)- and serotonin (5-HT)-mediated vasoconstriction and their associated effects on metabolism. Rat hindlimbs of various sizes were perfused using medium with or without erythrocytes at temperatures varying between 25 and 37°C. Varying these perfusion parameters altered the quantitative, but not qualitative, effects of the hormones.
In the hindlimb, infusion of NE stimulated both a1- and b-adrenoceptors (AR). The overall effect was the rapid onset of a sustained increase in perfusion pressure which was only slightly increased upon b-AR blockade. Energy for NE-stimulated vasoconstriction was supplied via aerobic means, involving oxidative formation of ATP. In addition, vasoconstriction appeared to be dependent on extracellular Ca2+, suggesting an a1A-AR-stimulated Ca2+ influx through plasma membrane channels.

Item Type: Thesis - PhD
Authors/Creators:Dora, Kim A(Andrea)
Keywords: Hindlimb, Metabolism
Copyright Holders: The Author
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Copyright 1993 the Author - The University is continuing to endeavour to trace the copyright
owner(s) and in the meantime this item has been reproduced here in good faith. We
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Includes bibliographical references. Thesis (Ph.D.)--University of Tasmania, 1994

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