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Abstract

It has been attempted in this thesis to compile information
available in the literature on the synthesis of some eight-membered
heterocyclic ring systems fused with one or two benzene rings
(benzo- and dibenzo- respectively), having one nitrogen (azocines),
two nitrogens (diazocines), and one nitrogen and one oxygen
(oxazocines) in the ring system. Literature up to the end of 1978
has been covered.
While this work was in progress, a similar report appeared in
Rodd's Chemistry of Carbon Compounds, Volume IV -K.
1 This review
article covers the literature up to the end of 1972 only and does
not include oxazocines. With the growing interest in the pharmacological activity of
medium rings, synthetic work in this area has seen a remarkable
increase during the 1970's. Figures 1 and 2 show the distribution of
publications during the period covered in this thesis, and it is
evident that a large amount of work has been carried out after 1972.
Synthetic work on dibenzodiazocines has been reported from the early
1880's, but only six publications appeared up to the end of 1920.
Relative positions of the hetero atoms and the ring fusion give
rise to a number of structural isomers in each benzo- and dibenzosystem.
The number of possible isomers and the number of isomers
reported (to the end of 1978) in each case is given in Table 1. All
the structural isomers of benz- and dibenzazocines are known, whereas
those ring systems containing nitrogen and . oxygen, oxazocines, are
less well known and should provide a fertile area for future synthetic endeavours.

Item Type:	Thesis - Unspecified
Authors/Creators:	Gunawardana, IWK
Keywords:	Heterocyclic compounds, Ring formation (Chemistry)
Copyright Holders:	The Author
Copyright Information:	Copyright 1980 the Author - The University is continuing to endeavour to trace the copyright owner(s) and in the meantime this item has been reproduced here in good faith. We would be pleased to hear from the copyright owner(s).
Additional Information:	Thesis (M.Sc.)--University of Tasmania, 1981.
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