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Abstract

This thesis describes research performed by myself, Simon Foote, from the
completion of my PhD until the date of submission. The research was
performed in three separate Institutes. The early work describing the
mapping of the Human Genome and the preceding, introductory project
mapping the Human Y Chromosome was performed at the Whitehead
Institute, MIT, Cambridge, USA. This work was done in the laboratories of
Professors David Page and Eric Lander. The work describing the host
responses to infectious disease and the genetics of susceptibility to multiple
sclerosis was performed in my own laboratory at the Walter and Eliza Hall
Institute (WEHI), Melbourne, Australia and more recently at the Menzies
Research Institute, University of Tasmania, Hobart, Australia. This
introductory chapter is not a review of the literature, but a synopsis of the
work attached as copied, published articles. The state of play of the field at
the time of publication of each of these articles can be found in the
introduction and discussion of each of these papers. While this collection of
papers may seem eclectic at first perusal, there is a strong genetics theme
underpinning all these topics.

Item Type:	Thesis - DSc
Authors/Creators:	Foote, SJ
Keywords:	Human genome, Communicable diseases, Multiple sclerosis, Genetics
Copyright Holders:	The Author
Copyright Information:	Copyright 2009 the Author - The University is continuing to endeavour to trace the copyright owner(s) and in the meantime this item has been reproduced here in good faith. We would be pleased to hear from the copyright owner(s).
Additional Information:	Thesis (DSc)--University of Tasmania, 2010. Includes bibliographical references. Introduction -- Mapping the human chromosome -- Host response to infectious disease -- Genetics of host susceptibility to plasmacytoma -- Genetic control of haemopoietic progenitor cell release -- Genetics of susceptibility to multiple sclerosis -- Other projects -- Summary -- References
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