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The differential amnesic effects of lorazepam and diazepam

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Leroi, Serena (1995) The differential amnesic effects of lorazepam and diazepam. Coursework Master thesis, University of Tasmania.

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Abstract

There have been many attempts to classify the functions of human memory. A
broad classificatory scheme that is currently in use is the division of memory
into explicit and implicit memory. Explicit memory refers to the conscious
retrieval of information relating to previous experiences (Schacter et al., 1993).
This form of memory is assessed using tasks involving the explicit recall
(immediate or delayed) of information that has been learned in an earlier study
phase. Implicit memory is responsible for the retrieval of stored information
without subjective awareness of the source of information (Donlon et al., 1993).
One of the most common functions of implicit memory is priming.
A number of experimental variables have been used to demonstrate the
distinction between implicit and explicit memory. These include shifts in
sensory modality between study and test phases (Berry & Dienes, 1991),
changes in the surface characteristics of stimuli (Roediger & Blaxton, 1987),
varied retention intervals (Tulving et al., 1982) and manipulation of the level of
encoding of target items during a study phase (Roediger et al., 1992).
The dissociation between explicit and implicit memory has also been
demonstrated in studies involving the administration of benzodiazepines. These
have found that benzodiazepines impair performance on explicit memory
measures, such as recall and recognition. (Danion et al., 1989, Fang et al., 1987,
File et al., 1992, Danion et al., 1992). These investigations focused primarily on
the administration of either lorazepam or diazepam.
When implicit memory measures are involved in benzodiazepine studies, it is
generally reported that implicit memory is not affected by the drugs. Studies
have found that priming remains intact after the ingestion of diazepam (Danion
et al., 1989, Fang et al., 1987, Danion et al., 1992). However, priming is
significantly reduced when lorazepam is administered (Knopman, 1991, Danion
et al., 1992, Brown et al., 1989). This review will examine the organisation of
memory, particularly the divisions and functions of explicit and implicit
memory. It will also explore the current evidence of the effects of
benzodiazepines on these aspects of memory.

Item Type: Thesis (Coursework Master)
Keywords: Lorazepam, Diazepam, Memory, Benzodiazepines
Copyright Holders: The Author
Copyright Information:

Copyright 1995 the Author - The University is continuing to endeavour to trace the copyright
owner(s) and in the meantime this item has been reproduced here in good faith. We
would be pleased to hear from the copyright owner(s).

Additional Information:

Includes bibliographical references (leaves 20-26). Thesis (M.Psych.)--University of Tasmania, 1996

Date Deposited: 19 Dec 2014 02:35
Last Modified: 14 Jul 2017 06:17
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