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Abstract

The tachykinins are a family of peptides found extensively throughout the mammalian
nervous system. In the brain stem, tachykinins, including substance P (SP) and
neurokinin A (NKA), are present in areas involved in the integration of cardiovascular
and respiratory reflexes. However, little is known of the role played by tachykinins
and tachykinin receptors at such sites. The overall aim of the studies presented in this
thesis was to describe the respiratory actions of tachykinins, the identity of the
receptors involved and subsequently examine the regulation of tachykinin receptors in
the rat brain stem, using both in vivo (respiratory response to microinjection of drugs
in to the commissural nucleus of the solitary tract (cNTS)) and in vitro techniques
(radioligand binding and autoradiography).

Item Type:	Thesis - PhD
Authors/Creators:	Mazzone, Stuart B
Keywords:	Peptides, Tachykinins
Copyright Holders:	The Author
Copyright Information:	Copyright 1999 the Author - The University is continuing to endeavour to trace the copyright owner(s) and in the meantime this item has been reproduced here in good faith. We would be pleased to hear from the copyright owner(s).
Additional Information:	Thesis (Ph.D.)--University of Tasmania, 2000. Includes bibliographical references
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