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Identification of potential genetic risk markers in familial primary open-angle glaucoma in Tasmania


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Wu, Johnny 2004 , 'Identification of potential genetic risk markers in familial primary open-angle glaucoma in Tasmania', Research Master thesis, University of Tasmania.

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Approximately 50% of all primary open-angle glaucoma (POAG) is familial.
Investigation of clinical risk factors associated with familial POAG may help to identify
phenotypic subtypes of the disease, each with different pathophysiologic mechanisms
that may be modified by intervention and disease-prevention strategies.
In a cross-sectional retrospective study of 2940 'glaucoma' patients over 10 years of age
in Tasmania, the prevalence of nine potential clinical risk factors (hypertension, diabetes
mellitus, migraine headache, corticosteroids use, smoking, atherosclerosis, cold
extremities, blood transfusion, thyroid disorders) were compared using multi-stepped
regression analysis between 1014 patients with familial glaucoma and 688 patients with
sporadic or non-familial glaucoma classified by Glaucoma Inheritance Study in Tasmania
(GIST) scores (intraocular pressure, optic disc and visual field changes) and genealogic
data. 59.6% of all subjects with POAG have a positive family history of POAG.
There is no significant difference in the distribution of gender between the familial and
sporadic POAG groups (OR 1.053; 95%CI 0.819-1.353).
No risk factor examined is significantly different in the familial glaucoma group in
comparison to the sporadic glaucoma group, after adjusting for confounding effects of
age and gender, GIST scores, degree of relatives or other potential clinical risk factors.
The distribution of GIST scores in the familial glaucoma group is skewed towards the
higher spectrum and is significantly different from that of the sporadic glaucoma group
(p<0.001), suggesting the likelihood of an earlier onset and/or a greater severity of
glaucoma in the familial group.

Item Type: Thesis - Research Master
Authors/Creators:Wu, Johnny
Keywords: Open-angle glaucoma
Copyright Holders: The Author
Copyright Information:

Copyright 2004 the Author - The University is continuing to endeavour to trace the copyright owner(s) and in the meantime this item has been reproduced here in good faith. We would be pleased to hear from the copyright owner(s).

Additional Information:

Thesis (M.Med.Sc.)--University of Tasmania, 2004. Includes bibliographical references

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