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Tachykinin receptor (NK(1), NK(2), NK(3)) binding sites in the rat caudal brainstem following neonatal capsaicin administration

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Geraghty, DP and Mazzone, SB 2003 , 'Tachykinin receptor (NK(1), NK(2), NK(3)) binding sites in the rat caudal brainstem following neonatal capsaicin administration' , Brain Research, vol. 979, no. 1-2 , pp. 230-234 , doi: 10.1016/S0006-8993(03)02871-3.

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Abstract

Binding of [125I]-Bolton–Hunter substance P ([125I]-BHSP), [125I]-neurokinin A and [3H]-senktide to tachykinin NK1, NK2 and NK3 receptors, respectively, was examined in caudal brainstem sections of 10-week-old rats pretreated as neonates (P2) with capsaicin (50 mg/kg, s.c.) or vehicle. [125I]-BHSP binding was localised to the nucleus of the solitary tract (NTS), hypoglossal nucleus and inferior olivary complex, whereas [125I]-neurokinin A and [3H]-senktide binding were confined to the NTS. The distribution and density of binding sites were similar in vehicle- and capsaicin-pretreated rats, suggesting that sensory neuron ablation by neonatal capsaicin does not affect tachykinin receptor numbers in the rat caudal brainstem.

Item Type: Article
Authors/Creators:Geraghty, DP and Mazzone, SB
Keywords: Neonatal capsaicin; Brain stem; Tachykinin receptors; Autoradiography
Journal or Publication Title: Brain Research
ISSN: 0006-8993
DOI / ID Number: 10.1016/S0006-8993(03)02871-3
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