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Polymorphisms in the tissue factor pathway inhibitor gene are not associated with ischaemic stroke


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Sayer, MS, Cole, VJ, Adams, MJ, Baker, RI and Staton, JM 2007 , 'Polymorphisms in the tissue factor pathway inhibitor gene are not associated with ischaemic stroke' , Blood Coagulation and Fibrinolysis, vol. 18, no. 7 , pp. 703-708 .

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The present study aimed to determine whether four
previously described polymorphisms found within the
tissue factor pathway inhibitor (TFPI) gene are associated
with free plasma TFPI levels or with TFPI activity as well as
the risk of ischaemic stroke in stroke patients and
control individuals. We conducted a case–control study of
162 first-ever ischaemic stroke cases and 170 randomly
selected community control individuals. The TFPI genotype
was determined for the T-287C, C-399T, Intron 7 C-33T, and
Val264Met (G874A) polymorphisms. Free plasma TFPI and
TFPI activity were measured during the first 7 days and
3–6 months after the acute stroke event. Free plasma TFPI
levels were significantly lowered 3–6 months after stroke
compared with levels observed in the patient group
during the acute phase of the stroke (mean, 16.3 versus
22.46 ng/ml; PU0.046) and among the control group
(mean, 16.3 versus 22.79 ng/ml; P<0.0001). Conversely,
TFPI activity was significantly up-regulated during the acute
phase (mean, 1.30 versus 1.11 U/ml; PU0.0051) and
remained elevated 3–6 months later (mean, 1.28 versus
1.11 U/ml; PU0.03). The TFPI gene polymorphisms studied
were not significantly associated with TFPI levels or activity,
nor with the risk of ischaemic stroke. In conclusion, the TFPI
activity and concentration in plasma varied significantly
after an ischaemic stroke; however, these variations
were not found to be due to the presence of any of the
genetic mutations analysed in this study. Our results are
consistent with the emerging model suggesting the
lipoprotein-bound portion of TFPI has a significant influence
on coagulation and diseases of haemostasis.

Item Type: Article
Authors/Creators:Sayer, MS and Cole, VJ and Adams, MJ and Baker, RI and Staton, JM
Journal or Publication Title: Blood Coagulation and Fibrinolysis
ISSN: 0957-5235
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