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Chlamydia trachomatis in Tasmania : improving public health surveillance methods to reduce the burden of disease

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Stephens, N (2016) Chlamydia trachomatis in Tasmania : improving public health surveillance methods to reduce the burden of disease. PhD thesis, University of Tasmania.

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Available under University of Tasmania Standard License.

[img] PDF (Whole thesis)
Stephens_whole_...pdf | Document not available for request/download
Full text restricted
Available under University of Tasmania Standard License.

Abstract

Background: Genital Chlamydia trachomatis (chlamydia) is Australia’s most frequently notified communicable disease. Associated costs have been estimated at between AUD$90-$160 million per year. Chlamydia infection can lead to significant health complications including infertility in both sexes. Public health surveillance data based on statutory notifications of cases provides epidemiological information useful in focussing chlamydia control efforts, however the data is limited without knowledge of testing patterns. Clinical guidelines recommend annual tests for all sexually active people aged <30 years, and mathematical modelling demonstrates that large reductions in chlamydia prevalence are possible, provided there is adequate testing coverage.

Aims: To investigate, in Tasmania: i) increasing rates of chlamydia notifications by demographic and risk profiles and behavioural characteristics; ii) rates of testing, retesting and test positivity; iii) the feasibility and usefulness of collecting population-level testing data; iv) potential clinical and behavioural influences on test positivity trends; v) whether testing effort is reaching strategic and clinical guidelines; vi) the role and type of healthcare provider in chlamydia testing.

Methods: Four Tasmanian datasets were analysed i) statutory data on all chlamydia cases notified from 2001-2010; ii) additional surveillance data collected on all notified cases of chlamydia from 2001-2010; iii) de-identified laboratory testing data collected from 2001-2010; and iv) linked laboratory testing data collected in 2012 and 2013. Data were analysed by sex, geographic location, indigenous status, sexual exposure, reason for testing and healthcare provider. Testing patterns and positivity levels were examined and compared with data collected on notified cases. Population rates of testing and retesting, and test positivity were measured by sex, healthcare provider, geographic location and socioeconomic indicators.

Results: Females were more likely to have been tested as a result of screening, males as a result of presenting with symptoms or from contact tracing. General practitioners identify the majority of cases. Testing and retesting rates are lower than recommended levels. Testing and test positivity increased from 2001 to 2010, most significantly in males and females aged 15-24 years; testing coverage was higher in females (21%) than males (6%) and test positivity was higher in males (16%) than females (10%). In 2012 and 2013, less testing and higher test positivity was found in areas of most disadvantage; retest rates at 3 months were low in males (10%) and females (14%), and retest positivity high in males (35%) and females (23%).

Conclusions: Chlamydia infection is a significant public health issue. After allowing for testing effort, an increase in notifications in young people was found in Tasmania. Testing levels are below those required to decrease chlamydia prevalence. Analysis of chlamydia testing, retesting and positivity trends can inform the development, monitoring and evaluation of prevention and control activities and improves the interpretation of notification data.

Item Type: Thesis (PhD)
Keywords: Infectious disease surveillance, public health, sexual health
Copyright Information:

Copyright 2016 the author

Additional Information:

Chapter 2 appears to be the equivalent of the peer reviewed version of the following article: Stephens, N., O’Sullivan, M., Coleman, D., Shaw, K., 2010. Chlamydia trachomatis in Tasmania 2001-2007: rising notification trends, Australian and New Zealand journal of public health, 34(2), 120-125, which has been published in final form at http://dx.doi.org/10.1111/j.1753-6405.2010.00494.x This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.

Chapter 4 appears to be the equivalent of the peer reviewed version of the following article: Stephens, N., Coleman, D., Shaw, K., O’Sullivan, M., Vally, H., Venn, A., 2010. Exploration of testing practices and population characteristics support an increase in chlamydia positivity in Tasmania between 2001 and 2010, Australian and New Zealand journal of public health, 40(4), 362-367 which has been published in final form at http://dx.doi.org/10.1111/1753-6405.12502 This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.

Chapter 5 appears to be the equivalent of a post-print version of an article published as: Stephens, N., Coleman, D., Shaw, K., O’Sullivan, M., McGregor, A., Cooley, L., Vally H, Venn, A., 2017. Testing for chlamydial infection: are we meeting clinical guidelines? Evidence from a state-level data linkage analysis for 15-29 year-olds, Sexual health, published online 14 June 2017

Chapter 6 appears to be the equivalent of the peer reviewed version of the following article: Stephens, N., Coleman, D., Shaw, K., Venn, A., 2017. Geographical differences in Chlamydia trachomatis testing in 15-29 year-olds in Tasmania: findings from a statewide laboratory data linkage study, Australian journal of rural health, 25(3), 182-184, which has been published in final form at https://doi.org/10.1111/ajr.12316 This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.

Chapter 7 appears to be the equivalent of a post-print version of an article published as: Stephens, N., Coleman, D., Shaw, K., O’Sullivan, M., McGregor, A., Cooley, L., Venn, A., 2017. Chlamydia retesting and retest positivity rates: results from a state-wide laboratory data linkage study in Tasmania, 2012–13, Sexual health, 14(3) 261-267

Date Deposited: 27 Apr 2017 02:25
Last Modified: 28 Aug 2017 03:50
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