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Dietary phytochemical intake from foods and health outcomes: a systematic review protocol and preliminary scoping


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Probst, YC, Guan, VX and Kent, K ORCID: 0000-0002-5330-7044 2017 , 'Dietary phytochemical intake from foods and health outcomes: a systematic review protocol and preliminary scoping' , BMJ Open, vol. 7, no. 2 , pp. 1-9 , doi: 10.1136/bmjopen-2016-013337.

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Introduction:Dietary phytochemicals are found inplant-based foods such as fruits, vegetables and grainsand may be categorised in a nested hierarchicalmanner with many hundred individual phytochemicalsidentified to date. To associate phytochemical intakeswith positive health outcomes, a fundamental step is toaccurately estimate the dietary phytochemical intakefrom foods reported. The purpose of this systematicreview protocol is to describe the process to beundertaken to summarise the evidence for food-baseddietary phytochemical intakes and health outcomes foradults.Methods and analysis: The review will beundertaken following the PRISMA guidelines and theCochrane Handbook for Systematic Reviews ofInterventions using the Review Manager software.Phytochemical subclasses ( phenolic acids, flavanols,etc) will be used to search for relevant studies usingthe Web of Science and Scopus scientific databases.The retrieved studies will be screened based oninclusion of natural whole food items and healthoutcomes. Phytochemical studies related tocardiovascular disease, cancer, overweight, glucosetolerance, digestive, reproductive, macular and bonehealth and mental disorders, fatigue and immunitywill be examined based on prior scoping. Theevidence will be aggregated by the food types andhealth outcomes. Comparison of differences in theoutcomes for randomised controlled trials andobservational studies will be undertaken.The strength of the review lies in its focus onwhole food items and health conditions rather thanone type of phytochemical related to one singlehealth condition. Subgroup and sensitivityanalyses will be conducted where an adequatenumber of publications are found per phytochemicalsubclass.Dissemination: By comparing the outcomes fromexperimental and observational studies, the reviewwill determine whether the overall conclusionsrelated to the phytochemical subclasses are thesame between study types for the identified healthconditions. This is useful to public healthpolicymakers and health professionals alike.

Item Type: Article
Authors/Creators:Probst, YC and Guan, VX and Kent, K
Keywords: phytochemical, health, food, systematic review, protocol
Journal or Publication Title: BMJ Open
Publisher: B M J Group
ISSN: 2044-6055
DOI / ID Number: 10.1136/bmjopen-2016-013337
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Licensed under Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)

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