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Preconditioning tDCS facilitates subsequent tDCS effect on skill acquisition in older adults

Fujiyama, H, Hinder, MR ORCID: 0000-0002-5240-4790, Barzideh, A, Van de Vijver, C, Badache, AC, Manrique-C, MN, Reissig, P, Zhang, X, Levin, O, Summers, JJ and Swinnen, SP 2017 , 'Preconditioning tDCS facilitates subsequent tDCS effect on skill acquisition in older adults' , Neurobiology of Aging, vol. 51 , pp. 31-42 , doi: 10.1016/j.neurobiolaging.2016.11.012.

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Abstract

Functional motor declines that often occur with advancing age—including reduced efficacy to learn new skills—can have a substantial impact on the quality of life. Recent studies using noninvasive brain stimulation indicate that priming the corticospinal system by lowering the threshold for the induction of long-term potentiation–like plasticity before skill training may facilitate subsequent skill learning. Here, we used “priming” protocol, in which we used transcranial direct current stimulation (tDCS) applying the cathode over the primary motor cortex (M1) before the anode placed over M1 during unimanual isometric force control training (FORCEtraining). Older individuals who received tDCS with the cathode placed over M1 before tDCS with the anode placed over M1 concurrent with FORCEtraining showed greater skill improvement and corticospinal excitability increases following the tDCS/FORCEtraining protocol compared with both young and older individuals who did not receive the preceding tDCS with the cathode placed over M1. The results suggested that priming tDCS protocols may be used in clinical settings to improve motor function and thus maintain the functional independence of older adults.

Item Type: Article
Authors/Creators:Fujiyama, H and Hinder, MR and Barzideh, A and Van de Vijver, C and Badache, AC and Manrique-C, MN and Reissig, P and Zhang, X and Levin, O and Summers, JJ and Swinnen, SP
Keywords: healthy aging; skill acquisition; homeostatic metaplasticity; transcranial direct current stimulation; primary motor cortex
Journal or Publication Title: Neurobiology of Aging
Publisher: Elsevier Science Inc
ISSN: 0197-4580
DOI / ID Number: 10.1016/j.neurobiolaging.2016.11.012
Copyright Information:

Copyright 2016 Elsevier Inc.

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