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Physicochemical stability of voriconazole in elastomeric devices

Harmanjeet, H, Zaidi, STR ORCID: 0000-0002-2031-1055, Ming, LC ORCID: 0000-0002-6971-1383, Wanandy, T ORCID: 0000-0003-4703-0488 and Patel, RP ORCID: 0000-0001-9344-1013 2017 , 'Physicochemical stability of voriconazole in elastomeric devices' , European Journal of Hospital Pharmacy , pp. 1-5 , doi: 10.1136/ejhpharm-2016-001170.

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Abstract

Objectives: Voriconazole is the drug of choice forinvasive aspergillosis (IA), a leading cause of mortalityand morbidity in immunocompromised patients. Prolongintravenous administration of voriconazole is oftenneeded in such patients due to high incidence of oralmucositis and unreliable bioavailability of oral dosageform. Administration of voriconazole through elastomericpump may facilitate early hospital discharge of clinicallystable immunocompromised patients needing prolongedintravenous treatment. Therefore, we investigated thephysicochemical stability of voriconazole in one of thecommonly used elastomeric pumps at three differenttemperatures for various time points.Methods: A total of 18 elastomeric pumps wereprepared and 6 containing 2 mg/mL of voriconazole (3 in0.9% sodium chloride and 3 in 5% glucose) were storedat either 4°C for 96 hours, 25°C for 4 hours or at 35°Cfor 4 hours. An aliquot withdrawn immediately beforestorage (time 0) and at various time points was analysedfor chemical stability using high-performance liquidchromatography and for physical stability using visual, pHand microscopic analyses.Results: Voriconazole was stable for at least 96 hours, 4hours and 4 hours at 4°C, 25°C and 35°C, respectively,when admixed with either 0.9% sodium chloride or5% glucose. No evidence of particle formation, colourchange or pH change was observed throughout thestudy period.Conclusions: These findings would allow early hospitaldischarge using elastomeric intravenous administrationof voriconazole in patients in whom oral route ofadministration is not available.

Item Type: Article
Authors/Creators:Harmanjeet, H and Zaidi, STR and Ming, LC and Wanandy, T and Patel, RP
Keywords: Chromatography, stability, elastomeric, out patient devices
Journal or Publication Title: European Journal of Hospital Pharmacy
Publisher: BMJ Publishing Group
ISSN: 2047-9956
DOI / ID Number: 10.1136/ejhpharm-2016-001170
Copyright Information:

© European Association of Hospital Pharmacists (unless otherwise stated in the text of the article) 2017. All rights reserved.

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