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The effect of varenicline and nicotine patch on smoking rate and satisfaction with smoking: an examination of the mechanism of action of two pre-quit pharmacotherapies

Lu, W, Chappell, KJ ORCID: 0000-0003-0842-6316, Walters, JAE, Jacobson, GA ORCID: 0000-0002-3409-8769, Patel, RP ORCID: 0000-0001-9344-1013, Schuz, N ORCID: 0000-0001-9010-5487 and Ferguson, SG ORCID: 0000-0001-7378-3497 2017 , 'The effect of varenicline and nicotine patch on smoking rate and satisfaction with smoking: an examination of the mechanism of action of two pre-quit pharmacotherapies' , Psychopharmacology, vol. 234, no. 13 , pp. 1969-1976 , doi: 10.1007/s00213-017-4604-y.

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Abstract

Objectives: In recent years, there has been growing researchinterest in using nicotine replacement medications to aidsmoking reduction prior to a quit attempt. Gaining a betterunderstanding of how treatments influence smoking reductionmay allow for better tailoring of treatments and, ultimately,better cessation outcomes. The objective of the current studywas to test the effects of the pre-quit use of varenicline andnicotine patch on smoking rate and satisfaction with smoking.Methods: All participants were required to attend up to fivestudy visit sections. Participants (n = 213) who were interestedin quitting were randomised (open-label) to receive either prequitpatch or varenicline (both treatments started 2 weeks priorto an assigned quit day, followed by 10 weeks post-quit) orstandard patch (10 weeks starting from an assigned quit day).Participants used modified smartphones to monitor theirsmoking in real time for 4 weeks.Results: Participants in the two pre-quit treatment groups reportedsignificant reductions in both their satisfaction withsmoking (p Conclusions: Pre-quit treatment caused reductions in satisfactionwith smoking and smoking rate. Satisfaction was associatedwith changes in smoking rate, but the relationship wasweak. As such, monitoring reductions in satisfaction do notappear to be a viable method of evaluating responsiveness totreatment.

Item Type: Article
Authors/Creators:Lu, W and Chappell, KJ and Walters, JAE and Jacobson, GA and Patel, RP and Schuz, N and Ferguson, SG
Keywords: nicotine patch, smoking cessation, varenicline
Journal or Publication Title: Psychopharmacology
Publisher: Springer-Verlag
ISSN: 0033-3158
DOI / ID Number: 10.1007/s00213-017-4604-y
Copyright Information:

Copyright 2017 Springer-Verlag Berlin Heidelberg

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