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The development and impact of heterotopic ossification in burns: a review of four decades of research

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Kornhaber, R ORCID: 0000-0001-6556-6775, Foster, N, Edgar, D, Visentin, D ORCID: 0000-0001-9961-4384, Ofir, E, Haik, J and Harats, M 2017 , 'The development and impact of heterotopic ossification in burns: a review of four decades of research' , Scars, Burns & Healing, vol. 3, no. 1 , pp. 1-20 , doi: 10.1177/2059513117695659.

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Abstract

Introduction: Heterotopic ossification (HO) is the formation of lamellar bone within connective and othertissue where bone should not form and is a rare complication after burn injury. However, it leads to severepain and distress, marked reduction in joint range of motion (ROM), impaired function and increasedhospital length of stay. The pathophysiology, incidence and risk factors of HO remain poorly understoodin burns and other traumas and the management, controversial. The aim of this comprehensive review,therefore, was to synthesise the available evidence on the development and treatment of HO after acuteburn injury.Methods: The review was based on a systematic search of five electronic databases PubMed, EMBASE, CINAHL,LILACS and Scopus.Results: Synthesis and analysis of the data highlighted that, despite the passage of time, little translatableevidence is available to guide any prevention, screening, diagnostic or pharmacological or physical managementprotocols.Discussion: Causes of HO remain confounded, therefore prevention is difficult. Although spontaneousresolution is possible, surgical resection remains the recommended treatment when ROM and activities ofdaily living are severely affected.Conclusion: The findings from this review indicate that multicentre data pooling is needed to understand theoptimum pathway to prevention, identification and treatment of HO in acute burn patients.

Item Type: Article
Authors/Creators:Kornhaber, R and Foster, N and Edgar, D and Visentin, D and Ofir, E and Haik, J and Harats, M
Keywords: Activities of daily living, bisphosphonate, burns, elbow, etidronate disodium, heterotopic ossification, HO, range of motion, review, surgical resection, trauma, ulnar nerve entrapment
Journal or Publication Title: Scars, Burns & Healing
Publisher: Sage Publications Ltd.
ISSN: 2059-5131
DOI / ID Number: 10.1177/2059513117695659
Copyright Information:

Copyright 2017 The Authors. Licensed under Creative Commons Attribution-NonCommercial 3.0 Unported (CC BY-NC 3.0) https://creativecommons.org/licenses/by-nc/3.0/

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