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A computational mechanistic investigation into the reduction of Pt(IV) prodrugs with two axial chlorides by biological reductants
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Ejehi, Z and Ariafard, A 
ORCID: 0000-0003-2383-6380 2017
, 'A computational mechanistic investigation into the reduction of Pt(IV) prodrugs with two axial chlorides by biological reductants'
, Chemical Communications, vol. 53, no. 8
, pp. 1413-1416
, doi: https://doi.org/10.1039/c6cc07834f.
ORCID: 0000-0003-2383-6380 2017
, 'A computational mechanistic investigation into the reduction of Pt(IV) prodrugs with two axial chlorides by biological reductants'
, Chemical Communications, vol. 53, no. 8
, pp. 1413-1416
, doi: https://doi.org/10.1039/c6cc07834f.
Full text not available from this repository.
Official URL: http://dx.doi.org/10.1039/c6cc07834f
Abstract
It is widely reported that the Pt(iv) prodrugs with two axial chlorido ligands are reduced by biological reductants via a chloride-bridged inner-sphere mechanism. By contrast, in this contribution, we demonstrate that although this approach might be true for the reductants with sulphur donors, the reduction by ascorbates preferentially occurs via an outer sphere mechanism.
| Item Type: | Article |
|---|---|
| Authors/Creators: | Ejehi, Z and Ariafard, A |
| Keywords: | Pt(IV) prodrugs, reduction, biological reductants, density functional theory (DFT) |
| Journal or Publication Title: | Chemical Communications |
| Publisher: | Royal Soc Chemistry |
| ISSN: | 1359-7345 |
| DOI / ID Number: | https://doi.org/10.1039/c6cc07834f |
| Copyright Information: | Copyright 2017 The Royal Society of Chemistry |
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| Item Statistics: | View statistics for this item |
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