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A computational mechanistic investigation into the reduction of Pt(IV) prodrugs with two axial chlorides by biological reductants

Ejehi, Z and Ariafard, A ORCID: 0000-0003-2383-6380 2017 , 'A computational mechanistic investigation into the reduction of Pt(IV) prodrugs with two axial chlorides by biological reductants' , Chemical Communications, vol. 53, no. 8 , pp. 1413-1416 , doi: 10.1039/c6cc07834f.

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Abstract

It is widely reported that the Pt(iv) prodrugs with two axial chlorido ligands are reduced by biological reductants via a chloride-bridged inner-sphere mechanism. By contrast, in this contribution, we demonstrate that although this approach might be true for the reductants with sulphur donors, the reduction by ascorbates preferentially occurs via an outer sphere mechanism.

Item Type: Article
Authors/Creators:Ejehi, Z and Ariafard, A
Keywords: Pt(IV) prodrugs, reduction, biological reductants, density functional theory (DFT)
Journal or Publication Title: Chemical Communications
Publisher: Royal Soc Chemistry
ISSN: 1359-7345
DOI / ID Number: 10.1039/c6cc07834f
Copyright Information:

Copyright 2017 The Royal Society of Chemistry

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