Open Access Repository

Associations of childhood and adult obesity with left ventricular structure and function

Yang, H, Huynh, QL ORCID: 0000-0003-1368-5160, Venn, AJ ORCID: 0000-0001-7090-1398, Dwyer, T and Marwick, TH ORCID: 0000-0001-9065-0899 2017 , 'Associations of childhood and adult obesity with left ventricular structure and function' , International Journal of Obesity, vol. 41, no. 4 , pp. 560-568 , doi: 10.1038/ijo.2016.234.

Full text not available from this repository.


Background: Overweight and obesity are associated with left ventricular (LV) dysfunction. We sought whether echocardiographic evidence of abnormal adult cardiac structure and function was related to childhood or adult adiposity.Methods: This study included 159 healthy individuals aged 7-15 years and followed until age 36-45 years. Anthropometric measurements were performed both at baseline and follow-up. Cardiac structure (indexed left atrial volume (LAVi), left ventricular mass (LVMi)) and LV function (global longitudinal strain (GLS), mitral e') were assessed using standard echocardiography at follow-up. Conventional cutoffs were used to define abnormal LAVi, LVMi, GLS and mitral annular e'.Results: Childhood body mass index (BMI) was correlated with LVMi (r = 0.25, P = 0.002), and child waist circumference was correlated with LVMi (r = 0.18, P = 0.03) and LAVi (r = 0.20, P = 0.01), but neither were correlated with GLS. One s.d. (by age and sex) increase in childhood BMI was associated with LV hypertrophy (relative risk: 2.04 (95% confidence interval (CI): 1.09, 3.78)) and LA enlargement (relative risk: 1.81 (95% CI: 1.02, 3.21)) independent of adult BMI, but the association was not observed with impaired GLS or mitral e'. Cardiac functional measures were more impaired in those who had normal BMI as child, but had high BMI in adulthood (P P > 0.33).Conclusions: Childhood adiposity is independently associated with structural cardiac disturbances (LVMi and LAVi). However, functional alterations (GLS and mitral e') were more frequently associated with adult overweight or obesity, independent of childhood adiposity.

Item Type: Article
Authors/Creators:Yang, H and Huynh, QL and Venn, AJ and Dwyer, T and Marwick, TH
Journal or Publication Title: International Journal of Obesity
Publisher: Nature Publishing Group
ISSN: 0307-0565
DOI / ID Number: 10.1038/ijo.2016.234
Copyright Information:

© 2017 Macmillan Publishers Limited, part of Springer Nature. All rights reserved.

Related URLs:
Item Statistics: View statistics for this item

Actions (login required)

Item Control Page Item Control Page