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Arterial reservoir characteristics and central-to-peripheral blood pressure amplification in the human upper limb

Peng, X, Schultz, MG ORCID: 0000-0003-3458-1811, Picone, DS ORCID: 0000-0002-4760-1634, Black, JA, Dwyer, N ORCID: 0000-0002-1583-8290, Roberts-Thomson, P, Davies, JE and Sharman, JE ORCID: 0000-0003-2792-0811 2017 , 'Arterial reservoir characteristics and central-to-peripheral blood pressure amplification in the human upper limb' , Journal of Hypertension, vol. 35, no. 9 , pp. 1825-1831 , doi: 10.1097/HJH.0000000000001400.

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Abstract

Background: Arterial reservoir characteristics are related to blood pressure (BP) and independently predict cardiovascular events. It is unknown if arterial reservoir characteristics are modified from the central-to-peripheral large arteries and whether there is a contributory role to BP amplification. The aim of this study was to assess central-to-peripheral changes in arterial reservoir characteristics and determine associations with BP.Methods: Reservoir pressure (RP) and excess pressure (XSP) were derived from intra-arterial BP waveforms among 51 participants (aged 63 ± 13 years, 63% men) undergoing clinically indicated cardiac angiography. BP waveforms were recorded in the ascending aorta, brachial (mid-humerus) and radial (wrist) arteries via catheter pull-back.Results: There was no significant difference in RP between arterial sites (54  ±  15, 53  ±  15 and 52  ±  17  mm Hg for the aorta, brachial and radial artery, respectively; P =  0.68). Conversely, XSP increased stepwise from the aorta to the brachial and radial arteries (24  ±  11, 42  ±  14 and 53  ±  16  mm Hg; P  P  =  0.004). There were highly significant associations between RP and SBP at all arterial sites (r  =  0.821, 0.649 and 0.708; P  r  =  0.121 and 0.508; z =  3.04; P =  0.004).Conclusion: Arterial reservoir characteristics are modified through the large arteries of the upper limb. Although RP remains relatively constant, XSP increases significantly and is highly related to BP (SBP and pulse pressure) amplification. These data provide a new understanding on arterial reservoir characteristics and large-artery BP physiology.

Item Type: Article
Authors/Creators:Peng, X and Schultz, MG and Picone, DS and Black, JA and Dwyer, N and Roberts-Thomson, P and Davies, JE and Sharman, JE
Keywords: arterial pressure, haemodynamics, reservoir, wave reflection
Journal or Publication Title: Journal of Hypertension
Publisher: Lippincott Williams & Wilkins
ISSN: 0263-6352
DOI / ID Number: 10.1097/HJH.0000000000001400
Copyright Information:

© 2017 Wolters Kluwer Health, Inc. Unauthorized reproduction of this article is prohibited.

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