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A role for the tissue factor pathway in the pathogenesis of the antiphospholipid syndrome


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Lean, SY and Adams, MJ 2007 , 'A role for the tissue factor pathway in the pathogenesis of the antiphospholipid syndrome' , Australian Journal of Medical Science, vol. 28, no. 3 , pp. 99-107 .

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The antiphospholipid syndrome (aPS) is a systemic autoimmune disorder that is characterised by
laboratory markers of antiphospholipid antibodies (aPL) as well as clinical manifestations such as arterial
and venous thrombosis, recurrent pregnancy loss and thrombocytopaenia. Although it is unclear precisely
what mechanism(s) lead to thrombosis in aPS, it is probable that the contribution of aPL such as anti-β-2-
glycoprotein-1 (anti-β2GP1) is signifi cant. Indeed, there is increasing evidence that aPL may interfere with
the tissue factor (TF) pathway of blood coagulation and its natural regulator tissue factor pathway inhibitor
(TFPI), thus contributing toward the development of thrombosis in aPS. This paper will therefore review
1) the TF pathway of blood coagulation and TFPI, 2) clinical and laboratory aspects of aPL and aPS,
and 3) interactions of aPL with the TF pathway, to highlight the potential signifi cance of these in the
pathogenesis of aPS.

Item Type: Article
Authors/Creators:Lean, SY and Adams, MJ
Keywords: Antiphospholipid antibodies; Antiphospholipid syndrome; Thrombosis; Tissue factor; Tissue factor pathway inhibitor
Journal or Publication Title: Australian Journal of Medical Science
ISSN: 1038-1643
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