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UiO-66@SiO2 core–shell microparticles as stationary phases for the separation of small organic molecules

Arrua, RD ORCID: 0000-0001-9057-294X, Peristyy, A ORCID: 0000-0002-9537-4202, Nesterenko, PN ORCID: 0000-0002-9997-0650, Das, A, D'Alessandro, DM and Hilder, EF ORCID: 0000-0002-4444-7870 2017 , 'UiO-66@SiO2 core–shell microparticles as stationary phases for the separation of small organic molecules' , Analyst, vol. 142 , pp. 517-524 , doi: 10.1039/c6an02344d.

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Composite particles containing the Zr-based metal–organic framework (MOF) UiO-66 were prepared using microwave-assisted solvothermal synthesis. Scanning electron microscopy, infrared spectroscopy, powder X-ray diffraction and nitrogen physisorption studies confirmed the deposition of 100–300 nm microporous particles with the UiO-66 topology on the surface of mesoporous 5 μm and non-porous 2.1 μm silica particles. The core–shell particles exhibited a unique flow-dependent separation selectivity (FDSS) effect which allows changes in both the retention and separation selectivity of small molecules by simple variation of the mobile phase flow rate under isocratic conditions. The impact of the loading of UiO-66 as well as the porosity of the underlying silica core (mesoporous and non-porous) on the FDSS effect was evaluated. The prepared adsorbents were also tested for the normal-phase (NP) and reversed-phase (RP) separation of xylene isomers, substituted benzenes and polyaromatic hydrocarbons (PAHs). Efficiencies of up to 32400 plates per m (styrene, k 1.59) and 37200 plates per m (anisole, k 2.90) were achieved under NP and RP modes, respectively. The results demonstrate the potential of novel MOF-based stationary phases for the separation of closely related compounds (e.g. positional isomers).

Item Type: Article
Authors/Creators:Arrua, RD and Peristyy, A and Nesterenko, PN and Das, A and D'Alessandro, DM and Hilder, EF
Keywords: high performance liquid chromatography, metal-organic framework, flow selectivity
Journal or Publication Title: Analyst
Publisher: Royal Soc Chemistry
ISSN: 0003-2654
DOI / ID Number: 10.1039/c6an02344d
Copyright Information:

Copyright 2017 The Royal Society of Chemistry

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