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Abstract

The potential of a recently developed pressurized hot water extraction (PHWE) method employing an unmodified household espresso machine to facilitate rapid bioprospecting was investigated. A survey of some 16 Australian native plant species identified three Correa (Rutaceae) species containing significant quantities of coumarin natural products. As part of this study, seselin, (+)-epoxysuberosin, alosin, (–)-meranzin and heraclenin were isolated and, subsequently, used to synthesize the related natural products (+)-trachypleuranin A and (–)-yuehgesin B. In addition, seselin, (+)-epoxysuberosin, alosin, and (–)-meranzin were found to inhibit NQO1 activity. Interestingly, (–)-meranzin showed inhibitory activity comparable to the known potent NQO1 inhibitor dicoumarol.

Item Type:	Article
Authors/Creators:	Deans, BJ and Just, J and Chhetri, J and Burt, LK and Smith, JN and Kilah, NL and de Salas, M and Guven, N and Bissember, AC and Smith, JA
Keywords:	bioprospecting, coumarins, drug discovery, natural products, pressurized hot water extraction
Journal or Publication Title:	ChemistrySelect
Publisher:	Wiley - V C H Verlag GmbH & Co. KGaA
ISSN:	2365-6549
DOI / ID Number:	10.1002/slct.201602006
Copyright Information:	Copyright 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
Related URLs:	UTAS Profile: Just, J Google Scholar: Kilah, NL UTAS Profile: Kilah, NL Google Scholar: Guven, N UTAS Profile: Guven, N UTAS Profile: Bissember, AC Google Scholar: Smith, JA UTAS Profile: Smith, JA
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