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Pressurized hot water extraction as a viable bioprospecting tool: isolation of coumarin natural products from previously unexamined Correa (Rutaceae) species






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Abstract
The potential of a recently developed pressurized hot water extraction (PHWE) method employing an unmodified household espresso machine to facilitate rapid bioprospecting was investigated. A survey of some 16 Australian native plant species identified three Correa (Rutaceae) species containing significant quantities of coumarin natural products. As part of this study, seselin, (+)-epoxysuberosin, alosin, (–)-meranzin and heraclenin were isolated and, subsequently, used to synthesize the related natural products (+)-trachypleuranin A and (–)-yuehgesin B. In addition, seselin, (+)-epoxysuberosin, alosin, and (–)-meranzin were found to inhibit NQO1 activity. Interestingly, (–)-meranzin showed inhibitory activity comparable to the known potent NQO1 inhibitor dicoumarol.
Item Type: | Article |
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Authors/Creators: | Deans, BJ and Just, J and Chhetri, J and Burt, LK and Smith, JN and Kilah, NL and de Salas, MF and Guven, N and Bissember, AC and Smith, JA |
Keywords: | bioprospecting, coumarins, drug discovery, natural products, pressurized hot water extraction |
Journal or Publication Title: | ChemistrySelect |
Publisher: | Wiley - V C H Verlag GmbH & Co. KGaA |
ISSN: | 2365-6549 |
DOI / ID Number: | 10.1002/slct.201602006 |
Copyright Information: | Copyright 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim |
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