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Pressurized hot water extraction as a viable bioprospecting tool: isolation of coumarin natural products from previously unexamined Correa (Rutaceae) species

Deans, BJ, Just, J, Chhetri, J, Burt, LK, Smith, JN, Kilah, NL ORCID: 0000-0002-0615-3791, de Salas, M, Guven, N ORCID: 0000-0003-3782-767X, Bissember, AC ORCID: 0000-0001-5515-2878 and Smith, JA ORCID: 0000-0001-6313-3298 2017 , 'Pressurized hot water extraction as a viable bioprospecting tool: isolation of coumarin natural products from previously unexamined Correa (Rutaceae) species' , ChemistrySelect, vol. 2, no. 8 , pp. 2439-2443 , doi: 10.1002/slct.201602006.

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Abstract

The potential of a recently developed pressurized hot water extraction (PHWE) method employing an unmodified household espresso machine to facilitate rapid bioprospecting was investigated. A survey of some 16 Australian native plant species identified three Correa (Rutaceae) species containing significant quantities of coumarin natural products. As part of this study, seselin, (+)-epoxysuberosin, alosin, (–)-meranzin and heraclenin were isolated and, subsequently, used to synthesize the related natural products (+)-trachypleuranin A and (–)-yuehgesin B. In addition, seselin, (+)-epoxysuberosin, alosin, and (–)-meranzin were found to inhibit NQO1 activity. Interestingly, (–)-meranzin showed inhibitory activity comparable to the known potent NQO1 inhibitor dicoumarol.

Item Type: Article
Authors/Creators:Deans, BJ and Just, J and Chhetri, J and Burt, LK and Smith, JN and Kilah, NL and de Salas, M and Guven, N and Bissember, AC and Smith, JA
Keywords: bioprospecting, coumarins, drug discovery, natural products, pressurized hot water extraction
Journal or Publication Title: ChemistrySelect
Publisher: Wiley - V C H Verlag GmbH & Co. KGaA
ISSN: 2365-6549
DOI / ID Number: 10.1002/slct.201602006
Copyright Information:

Copyright 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

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