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Abstract

Objectives: To assess the overall effect of vitamin D supplementation on risk of acute respiratory tract infection, and to identify factors modifying this effect.Design: Systematic review and meta-analysis of individual participant data (IPD) from randomised controlled trials.Data sources: Medline, Embase, the Cochrane Central Register of Controlled Trials, Web of Science, ClinicalTrials.gov, and the International Standard Randomised Controlled Trials Number registry from inception to December 2015.Eligibility criteria for study selection: Randomised, double blind, placebo controlled trials of supplementation with vitamin D3 or vitamin D2 of any duration were eligible for inclusion if they had been approved by a research ethics committee and if data on incidence of acute respiratory tract infection were collected prospectively and prespecified as an efficacy outcome.Results: 25 eligible randomised controlled trials (total 11 321 participants, aged 0 to 95 years) were identified. IPD were obtained for 10 933 (96.6%) participants. Vitamin D supplementation reduced the risk of acute respiratory tract infection among all participants (adjusted odds ratio 0.88, 95% confidence interval 0.81 to 0.96; P for heterogeneity Conclusions: Vitamin D supplementation was safe and it protected against acute respiratory tract infection overall. Patients who were very vitamin D deficient and those not receiving bolus doses experienced the most benefit.

Item Type:	Article
Authors/Creators:	Martineau, AR and Jolliffe, DA and Hooper, RL and Greenberg, L and Aloia, JF and Bergman, P and Dubnov-Raz, G and Esposito, S and Ganmaa, D and Ginde, AA and Goodall, EC and Grant, CC and Griffiths, CJ and Janssens, W and Laaksi, I and Manaseki-Holland, S and Mauger, D and Murdoch, DR and Neale, R and Rees, JR and Simpson Jr, S and Stelmach, I and Kumar, GT and Urashima, M and Camargo Jr, CA
Journal or Publication Title:	BMJ
Publisher:	BMJ Group
ISSN:	1756-1833
DOI / ID Number:	10.1136/bmj.i6583
Copyright Information:	Copyright 2017 The Author(s)Licensed under Creative Commons Attribution 3.0 Unported (CC BY 3.0)https://creativecommons.org/licenses/by/3.0/
Related URLs:	UTAS Profile: Simpson Jr, S
Item Statistics:	View statistics for this item

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