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Vitamin D supplementation to prevent acute respiratory tract infections: Systematic review and meta-analysis of individual participant data

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Martineau, AR, Jolliffe, DA, Hooper, RL, Greenberg, L, Aloia, JF, Bergman, P, Dubnov-Raz, G, Esposito, S, Ganmaa, D, Ginde, AA, Goodall, EC, Grant, CC, Griffiths, CJ, Janssens, W, Laaksi, I, Manaseki-Holland, S, Mauger, D, Murdoch, DR, Neale, R, Rees, JR, Simpson Jr, S ORCID: 0000-0001-6521-3056, Stelmach, I, Kumar, GT, Urashima, M and Camargo Jr, CA 2017 , 'Vitamin D supplementation to prevent acute respiratory tract infections: Systematic review and meta-analysis of individual participant data' , BMJ, vol. 356 , pp. 1-14 , doi: 10.1136/bmj.i6583.

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Abstract

Objectives: To assess the overall effect of vitamin D supplementation on risk of acute respiratory tract infection, and to identify factors modifying this effect.Design: Systematic review and meta-analysis of individual participant data (IPD) from randomised controlled trials.Data sources: Medline, Embase, the Cochrane Central Register of Controlled Trials, Web of Science, ClinicalTrials.gov, and the International Standard Randomised Controlled Trials Number registry from inception to December 2015.Eligibility criteria for study selection: Randomised, double blind, placebo controlled trials of supplementation with vitamin D3 or vitamin D2 of any duration were eligible for inclusion if they had been approved by a research ethics committee and if data on incidence of acute respiratory tract infection were collected prospectively and prespecified as an efficacy outcome.Results: 25 eligible randomised controlled trials (total 11 321 participants, aged 0 to 95 years) were identified. IPD were obtained for 10 933 (96.6%) participants. Vitamin D supplementation reduced the risk of acute respiratory tract infection among all participants (adjusted odds ratio 0.88, 95% confidence interval 0.81 to 0.96; P for heterogeneity Conclusions: Vitamin D supplementation was safe and it protected against acute respiratory tract infection overall. Patients who were very vitamin D deficient and those not receiving bolus doses experienced the most benefit.

Item Type: Article
Authors/Creators:Martineau, AR and Jolliffe, DA and Hooper, RL and Greenberg, L and Aloia, JF and Bergman, P and Dubnov-Raz, G and Esposito, S and Ganmaa, D and Ginde, AA and Goodall, EC and Grant, CC and Griffiths, CJ and Janssens, W and Laaksi, I and Manaseki-Holland, S and Mauger, D and Murdoch, DR and Neale, R and Rees, JR and Simpson Jr, S and Stelmach, I and Kumar, GT and Urashima, M and Camargo Jr, CA
Journal or Publication Title: BMJ
Publisher: BMJ Group
ISSN: 1756-1833
DOI / ID Number: 10.1136/bmj.i6583
Copyright Information:

Copyright 2017 The Author(s)Licensed under Creative Commons Attribution 3.0 Unported (CC BY 3.0)https://creativecommons.org/licenses/by/3.0/

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