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Effectiveness of targeted screening for chronic kidney disease in the community setting: a systematic review

Gheewala, PA, Razi Zaidi, ST ORCID: 0000-0002-2031-1055, Jose, MD ORCID: 0000-0002-9589-0071, Bereznicki, L ORCID: 0000-0003-3974-3437, Peterson, GM ORCID: 0000-0002-6764-3882 and Castelino, RL 2017 , 'Effectiveness of targeted screening for chronic kidney disease in the community setting: a systematic review' , Journal of Nephrology , pp. 1-10 , doi: 10.1007/s40620-017-0375-0.

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Background: Targeted screening interventions for chronickidney disease (CKD) are increasingly being implementedin various community settings. However, the overall successof these programs is uncertain. Therefore, the aim ofthis review is to determine whether targeted screening iseffective in detecting people with undiagnosed CKD.Methods: We performed a systematic literature review,and included studies of targeted screening interventionimplemented in any community-based setting. Studies wererequired to have targeted people aged≥18 years, and multipleCKD risk factors from the following: diabetes, hypertension,cardiovascular disease and family history of kidneydisease. The outcome measures were percentages of participantswith positive screening test results and diagnosedwith CKD at follow-up.Results: Nine studies met the inclusion criteria. Eightstudies reported the percentage of participants with positivescreening test results, which ranged from 7 to 60.3%. Onlytwo studies repeated the diagnostic tests to detect CKD,and confirmed the chronicity of CKD in 20.5 and 17.1%of screened participants. The most commonly used screeningtests were albumin creatinine ratio (≥3.4  mg/mmol),and estimated glomerular filtration rate (eGFR) (Conclusions: This systematic review found significantvariation in the methods that were used to detect CKD,with the majority of studies reporting results based on onlysingle albuminuria or eGFR values. Future targeted screeningprograms should appropriately use the 2012 KDIGOguidelines in order to detect CKD, which is necessary todetermine the benefit of these programs when implementedin community-settings.

Item Type: Article
Authors/Creators:Gheewala, PA and Razi Zaidi, ST and Jose, MD and Bereznicki, L and Peterson, GM and Castelino, RL
Keywords: Chronic kidney disease · Targeted screening · Community setting · Early detection · Effectiveness · Systematic review
Journal or Publication Title: Journal of Nephrology
Publisher: Springer
ISSN: 1724-6059
DOI / ID Number: 10.1007/s40620-017-0375-0
Copyright Information:

© Italian Society of Nephrology 2017

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