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Determination of skeletal muscle microvascular flowmotion with contrast-enhanced ultrasound

Blackwood, SJ, Dwyer, RM ORCID: 0000-0001-8361-2712, Bradley, EA, Keske, MA ORCID: 0000-0003-4214-7628, Richards, SM ORCID: 0000-0002-5988-0423 and Rattigan, S ORCID: 0000-0001-6172-3040 2017 , 'Determination of skeletal muscle microvascular flowmotion with contrast-enhanced ultrasound' , Ultrasound in Medicine and Biology, vol. 43, no. 9 , pp. 2013-2023 , doi: 10.1016/j.ultrasmedbio.2017.05.012.

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Most methods of assessing flowmotion (rhythmic oscillation of blood flow through tissue) are limited to small sections of tissue and are invasive in tissues other than skin. To overcome these limitations, we adapted the contrast-enhanced ultrasound (CEUS) technique to assess microvascular flowmotion throughout a large region of tissue, in a non-invasive manner and in real time. Skeletal muscle flowmotion was assessed in anaesthetised Sprague Dawley rats, using CEUS and laser Doppler flowmetry (LDF) for comparison. Wavelet transformation of CEUS and LDF data was used to quantify flowmotion. The α-adrenoceptor antagonist phentolamine was infused to predictably blunt the neurogenic component of flowmotion. Both techniques identified similar flowmotion patterns, validating the use of CEUS to assess flowmotion. This study demonstrates for the first time that the novel technique of CEUS can be adapted for determination of skeletal muscle flowmotion in large regions of skeletal muscle.

Item Type: Article
Authors/Creators:Blackwood, SJ and Dwyer, RM and Bradley, EA and Keske, MA and Richards, SM and Rattigan, S
Keywords: contrast enhanced ultrasound, flowmotion, laser Doppler flowmetry
Journal or Publication Title: Ultrasound in Medicine and Biology
Publisher: Elsevier Science Inc
ISSN: 0301-5629
DOI / ID Number: 10.1016/j.ultrasmedbio.2017.05.012
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© 2017 World Federation for Ultrasound in Medicine & Biology

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