Open Access Repository
Determination of skeletal muscle microvascular flowmotion with contrast-enhanced ultrasound




Full text not available from this repository.
Abstract
Most methods of assessing flowmotion (rhythmic oscillation of blood flow through tissue) are limited to small sections of tissue and are invasive in tissues other than skin. To overcome these limitations, we adapted the contrast-enhanced ultrasound (CEUS) technique to assess microvascular flowmotion throughout a large region of tissue, in a non-invasive manner and in real time. Skeletal muscle flowmotion was assessed in anaesthetised Sprague Dawley rats, using CEUS and laser Doppler flowmetry (LDF) for comparison. Wavelet transformation of CEUS and LDF data was used to quantify flowmotion. The α-adrenoceptor antagonist phentolamine was infused to predictably blunt the neurogenic component of flowmotion. Both techniques identified similar flowmotion patterns, validating the use of CEUS to assess flowmotion. This study demonstrates for the first time that the novel technique of CEUS can be adapted for determination of skeletal muscle flowmotion in large regions of skeletal muscle.
Item Type: | Article |
---|---|
Authors/Creators: | Blackwood, SJ and Dwyer, RM and Bradley, EA and Keske, MA and Richards, SM and Rattigan, S |
Keywords: | contrast enhanced ultrasound, flowmotion, laser Doppler flowmetry |
Journal or Publication Title: | Ultrasound in Medicine and Biology |
Publisher: | Elsevier Science Inc |
ISSN: | 0301-5629 |
DOI / ID Number: | 10.1016/j.ultrasmedbio.2017.05.012 |
Copyright Information: | © 2017 World Federation for Ultrasound in Medicine & Biology |
Related URLs: | |
Item Statistics: | View statistics for this item |
Actions (login required)
![]() |
Item Control Page |