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The BDNF Val66Met polymorphism moderates the effect of cognitive reserve on 36-month cognitive change in healthy older adults

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Ward, D ORCID: 0000-0001-5476-9526, Andel, R, Saunders, NLJ ORCID: 0000-0003-4609-114X, Thow, M, Klekociuk, SZ ORCID: 0000-0001-8654-2924, Bindoff, AD ORCID: 0000-0002-0943-2702 and Vickers, JC ORCID: 0000-0001-5671-4879 2017 , 'The BDNF Val66Met polymorphism moderates the effect of cognitive reserve on 36-month cognitive change in healthy older adults' , Alzheimer’s & Dementia: Translational Research & Clinical Interventions, vol. 3, no. 3 , pp. 323-331 , doi: 10.1016/j.trci.2017.04.006.

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Abstract

Introduction: Cognitive reserve (CR) and BDNF Val66Met are independently associated with therate of cognitive decline in preclinical Alzheimer’s disease. This study was designed to investigatethe interactive effects of these variables on 36-month cognitive change in cognitively intact olderadults.Methods: Data for this investigation were obtained from 445 community-residing participants of theTasmanian Healthy Brain Project, who underwent genetic screening and annual assessment ofneuropsychological, health, and psychosocial function.Results: Our main result was that BDNF Val66Met moderated the relationship between baseline CRand change in executive function performance, in that CR-related differences in function decreasedacross the follow-up period in BDNF Val homozygotes, but became more pronounced in BDNF Metcarriers. Similar effects were not observed within the other memory- and language-related cognitivedomains.Discussion: Inheritance of BDNF Met may be associated with a detrimental influence on the relationshipbetween CR and cognitive change in cognitively intact older adults, but this effect may berestricted to the executive function domain.cognitively intact older adults, but this effect may berestricted to the executive function domain.

Item Type: Article
Authors/Creators:Ward, D and Andel, R and Saunders, NLJ and Thow, M and Klekociuk, SZ and Bindoff, AD and Vickers, JC
Keywords: Cognitive reserve; brain reserve; brain-derived neurotrophic factor; bdnf; aging; cognitive function; cognitive change
Journal or Publication Title: Alzheimer’s & Dementia: Translational Research & Clinical Interventions
Publisher: Elsevier Inc.
ISSN: 2352-8737
DOI / ID Number: 10.1016/j.trci.2017.04.006
Copyright Information:

Copyright 2017 The Authors. Published by Elsevier Inc. on behalf of the Alzheimer’s Association. This is an open access article under the CC BY-NC-NDlicense (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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