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Abstract

Systemic inflammation is an integral part of chronic obstructive pulmonary disease (COPD), and air pollution is associated with cardiorespiratory mortality, yet the interrelationships are not fully defined. We examined associations between nitrogen dioxide (NO₂) exposure (as a marker of traffic-related air pollution) and pro-inflammatory cytokines, and investigated effect modification and mediation by post-bronchodilator airflow obstruction (post-BD-AO) and cardiovascular risk. Data from middle-aged participants in the Tasmanian Longitudinal Health Study (TAHS, n = 1389) were analyzed by multivariable logistic regression, using serum interleukin (IL)-6, IL-8 and tumor necrosis factor-α (TNF-α) as the outcome. Mean annual NO₂ exposure was estimated at residential addresses using a validated satellite-based land-use regression model. Post-BD-AO was defined by post-BD forced expiratory ratio (FEV₁/FVC) p = 0.001) per quartile increase in NO₂). This was predominantly a direct relationship, with little evidence for either effect modification or mediation via post-BD-AO, or for the small subgroup who reported cardiovascular events. However, there was some evidence consistent with serum IL-6 being on the causal pathway between NO₂ and cardiovascular risk. These findings raise the possibility that the interplay between air pollution and systemic inflammation may differ between post-BD airflow obstruction and cardiovascular diseases.

Item Type:	Article
Authors/Creators:	Perret, JL and Bowatte, G and Lodge, CJ and Knibbs, LD and Gurrin, LC and Kandane-Rathnayake, R and Johns, DP and Lowe, AJ and Burgess, JA and Thompson, BR and Thomas, PS and Wood-Baker, R and Morrison, S and Giles, GG and Marks, G and Markos, J and Tang, MLK and Abramson, MJ and Walters, EH and Matheson, MC and Dharmage, SC
Keywords:	Pollution, nitogen dioxide, lung function
Journal or Publication Title:	International Journal of Molecular Sciences
Publisher:	MDPI
ISSN:	1661-6596
DOI / ID Number:	https://doi.org/10.3390/ijms18051015
Copyright Information:	© 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Related URLs:	UTAS Profile: Walters, EH
Item Statistics:	View statistics for this item

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