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Environmental novelty exacerbates stress hormones and Aβ pathology in an Alzheimer’s model

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Stuart, K ORCID: 0000-0002-7872-4231, King, AE ORCID: 0000-0003-1792-0965, Fernandez-Martos, CM ORCID: 0000-0002-6387-4456, Summers, MJ ORCID: 0000-0002-3869-4920 and Vickers, JC ORCID: 0000-0001-5671-4879 2017 , 'Environmental novelty exacerbates stress hormones and Aβ pathology in an Alzheimer’s model' , Scientific Reports, vol. 7, no. 1 , pp. 1-7 , doi: 10.1038/s41598-017-03016-0.

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Abstract

Cognitive stimulation has been proposed as a non-pharmacological intervention to be used in primary, secondary and tertiary prevention approaches for Alzheimer’s disease. A common familial Alzheimer’s disease transgenic model showed heightened levels of the stress hormone, corticosterone. When exposed to periodic enhanced cognitive stimulation, these animals demonstrated further heightened levels of corticosterone as well as increased Aβ pathology. Hence, Alzheimer’s disease may be associated with hypothalamic-pituitary-adrenal (HPA) axis dysfunction, causing stimulatory environments to become stress-inducing, leading to a glucocorticoid-pathology cycle contributing to further Aβ release and plaque formation. This finding suggests that stimulation-based interventions and local environments for people with Alzheimer’s disease need to be designed to minimise a stress response that may exacerbate brain pathology.

Item Type: Article
Authors/Creators:Stuart, K and King, AE and Fernandez-Martos, CM and Summers, MJ and Vickers, JC
Keywords: Alzheimer's disease, amyloid pathology, stress, environmental enrichment
Journal or Publication Title: Scientific Reports
Publisher: Nature Publishing Group
ISSN: 2045-2322
DOI / ID Number: 10.1038/s41598-017-03016-0
Copyright Information:

Copyright 2017 The Authors. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/

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