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Environmental novelty exacerbates stress hormones and Aβ pathology in an Alzheimer’s model
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Abstract
Cognitive stimulation has been proposed as a non-pharmacological intervention to be used in primary, secondary and tertiary prevention approaches for Alzheimer’s disease. A common familial Alzheimer’s disease transgenic model showed heightened levels of the stress hormone, corticosterone. When exposed to periodic enhanced cognitive stimulation, these animals demonstrated further heightened levels of corticosterone as well as increased Aβ pathology. Hence, Alzheimer’s disease may be associated with hypothalamic-pituitary-adrenal (HPA) axis dysfunction, causing stimulatory environments to become stress-inducing, leading to a glucocorticoid-pathology cycle contributing to further Aβ release and plaque formation. This finding suggests that stimulation-based interventions and local environments for people with Alzheimer’s disease need to be designed to minimise a stress response that may exacerbate brain pathology.
Item Type: | Article |
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Authors/Creators: | Stuart, K and King, AE and Fernandez-Martos, CM and Summers, MJ and Vickers, JC |
Keywords: | Alzheimer's disease, amyloid pathology, stress, environmental enrichment |
Journal or Publication Title: | Scientific Reports |
Publisher: | Nature Publishing Group |
ISSN: | 2045-2322 |
DOI / ID Number: | 10.1038/s41598-017-03016-0 |
Copyright Information: | Copyright 2017 The Authors. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/ |
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