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Associations between systemic bone mineral density, knee cartilage defects and bone marrow lesions in patients with knee osteoarthritis

Zhu, Q, Xu, J, Wang, K, Cai, J, Wu, J, Ren, J, Zheng, S ORCID: 0000-0003-3552-1247 and Ding, C ORCID: 0000-0002-9479-730X 2017 , 'Associations between systemic bone mineral density, knee cartilage defects and bone marrow lesions in patients with knee osteoarthritis' , International Journal of Rheumatic Diseases , pp. 1-9 , doi: 10.1111/1756-185X.13148.

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Abstract

Aim: The relationship between bone mineral density (BMD) and osteoarthritis (OA) remains controversial. This study aimed to explore the cross-sectional associations between BMD at the total body, hip and spine and joint structural abnormalities including cartilage defects and bone marrow lesions (BMLs) in patients with knee OA.Method: One hundred and eight-five subjects with symptomatic knee OA were included in this study. T2-weighted fast spin echo magnetic resonance imaging was used to assess knee cartilage defects and BMLs. Total body, hip and spine BMD were measured using dual-energy X-ray absorptiometry.Results: After adjustment for potential confounders, total hip BMD was negatively associated with medial tibial cartilage defects, lateral femoral cartilage defects, medial tibial BMLs and lateral tibial BMLs. Spine and total body BMD were negatively associated with lateral femoral cartilage defects, but not with BMLs.Conclusion: We concluded that BMD particularly at the hip was negatively associated with knee cartilage defects and BMLs.

Item Type: Article
Authors/Creators:Zhu, Q and Xu, J and Wang, K and Cai, J and Wu, J and Ren, J and Zheng, S and Ding, C
Keywords: osteoarthritis, bone mineral density, knee, magnetic resonance imaging
Journal or Publication Title: International Journal of Rheumatic Diseases
Publisher: Wiley-Blackwell Publishing Asia
ISSN: 1756-1841
DOI / ID Number: 10.1111/1756-185X.13148
Copyright Information:

© 2017 Asia Pacific League of Associations for Rheumatology and John Wiley & Sons Australia, Ltd

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