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Abstract

The precision with which neurons form connections is crucial for the normal development and function of thenervous system. The development of neuronal circuitry in the nervous system is accomplished by axon pathfinding:a process where growth cones guide axons through the embryonic environment to connect with theirappropriate synaptic partners to form functional circuits. Despite intense efforts over many years to understandhow this process is regulated, the complete repertoire of molecular mechanisms that govern the growth conecytoskeleton and hence motility, remain unresolved. A central tenet in the axon guidance field is that calciumsignals regulate growth cone behaviours such as extension, turning and pausing by regulating rearrangements ofthe growth cone cytoskeleton. Here, we provide evidence that not only the amplitude of a calcium signal iscritical for growth cone motility but also the source of calcium mobilisation. We provide an example of this ideaby demonstrating that manipulation of calcium signalling via L-type voltage gated calcium channels can perturbsensory neuron motility towards a source of netrin-1. Understanding how calcium signals can be transduced toinitiate cytoskeletal changes represents a significant gap in our current knowledge of the mechanisms thatgovern axon guidance, and consequently the formation of functional neural circuits in the developing nervoussystem.

Item Type:	Article
Authors/Creators:	Gasperini, RJ and Pavez, MP and Thompson, AC and Mitchell, Camila and Hardy, H and Young, KM and Chilton, JK and Foa, L
Keywords:	Growth cone, Calcium, Axon guidance, Cytoskeleton, Endoplasmic reticulum (ER), Microtubules, Actin
Journal or Publication Title:	Molecular and Cellular Neurosciences
Publisher:	Academic Press Inc Elsevier Science
ISSN:	1044-7431
DOI / ID Number:	https://doi.org/10.1016/j.mcn.2017.07.006
Copyright Information:	Copyright 2017 Crown Copyright. Licensed under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)https://creativecommons.org/licenses/by-nc-nd/4.0/
Related URLs:	UTAS Profile: Gasperini, RJ UTAS Profile: Young, KM Google Scholar: Foa, L UTAS Profile: Foa, L
Item Statistics:	View statistics for this item

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