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Abstract

During an immune response inflammatory macrophages with their wide variety of effector mechanisms including the expression of inducible nitric oxide synthase play an important part in the defense against invading pathogens. The inflammatory phenotype requires the presence of TNF which suppresses alternative activation. In the bacterial Listeria monocytogenes infection model inflammatory macrophages are crucial for protection. After infection, TNF-deficient hosts have a similar number of splenic macrophages but die rapidly. A more detailed analysis of these cells showed that while inducible nitric oxide synthase is expressed at a comparable level TNF-deficient macrophages show an increased expression of Arginase 1.

Item Type:	Article
Authors/Creators:	Li, X and Lyons, AB and Woods, GM and Korner, H
Keywords:	macrophages, tumor necrosis factor, cell differentiation, listeria monocytogenes
Journal or Publication Title:	Immunobiology
Publisher:	Urban & Fischer Verlag
ISSN:	0171-2985
DOI / ID Number:	https://doi.org/10.1016/j.imbio.2017.05.012
Copyright Information:	© 2017 Elsevier GmbH. All rights reserved.
Related URLs:	Google Scholar: Lyons, AB UTAS Profile: Lyons, AB Google Scholar: Woods, GM UTAS Profile: Woods, GM Google Scholar: Korner, H UTAS Profile: Korner, H
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