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Targeting Pericytes and the Microcirculation for Ischemic Stroke Therapy

Neuhaus, AA, Sutherland, B ORCID: 0000-0002-0791-0950 and Buchan, AM 2017 , 'Targeting Pericytes and the Microcirculation for Ischemic Stroke Therapy', in PA Lapchak and JH Zhang (eds.), Neuroprotective Therapy for Stroke and Ischemic Disease , Springer International Publishing, Switzerland, pp. 537-556.

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Ischaemic stroke is a major global cause of disability and death, yet thetherapeutic options currently available for stroke are very limited. The only effectiveacute treatments of ischemic stroke revolve around restoring patency to theoccluded artery through degradation (intravenous thrombolysis) or mechanicalremoval of the clot [Int J Stroke 10:1168–1178, 2015; Brain 136:3528–3553, 2013].However, there is an increasing body of evidence to suggest that even followingrecanalization of the large vessel, the post-ischemic microvasculature remains dysfunctionaland does not necessarily allow effective reperfusion. Contributors to thisphenomenon include astrocyte swelling and compression of microvessels, obstructionof flow due to inflammatory changes, leukocyte adhesion and thrombosis, andthe constriction of capillaries by pericytes dying in rigor [Shock 8:95–101, 1997; JCereb Blood Flow 36:451–455, 2016]. This chapter will provide an overview ofmicrovascular function in health, describe the pathological changes that occur followingischemia and reperfusion, and explore the role of the microvasculature, witha focus on pericytes as a potential therapeutic target in ischemic stroke.

Item Type: Book Section
Authors/Creators:Neuhaus, AA and Sutherland, B and Buchan, AM
Keywords: Pericyte, blood flow, stroke, brain
Publisher: Springer International Publishing
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Copyright 2017 Springer International Publishing Switzerland

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