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The IMPROVE Guidelines (Ischaemia Models: Procedural Refinements Of in Vivo Experiments)

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Percie du Sert, N, Alfieri, A, Allan, SM, Carswell, HV, Deuchar, GA, Farr, TD, Flecknell, P, Gallagher, L, Gibson, CL, Haley, MJ, Macleod, MR, McColl, BW, McCabe, C, Morancho, A, Moon, LD, O'Neill, MJ, Pe'rez de Puig, I, Planas, A, Ragan, CI, Rosell, A, Roy, LA, Ryder, KO, Simats, A, Sena, ES, Sutherland, BA ORCID: 0000-0002-0791-0950, Tricklebank, MD, Trueman, RC, Whitfield, L, Wong, R and Macrae, IM 2017 , 'The IMPROVE Guidelines (Ischaemia Models: Procedural Refinements Of in Vivo Experiments)' , Journal of Cerebral Blood Flow and Metabolism, vol. 37, no. 11 , 3488–3517 , doi: 10.1177/0271678X17709185.

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Abstract

Most in vivo models of ischaemic stroke target the middle cerebral artery and a spectrum of stroke severities, from mildto substantial, can be achieved. This review describes opportunities to improve the in vivo modelling of ischaemic strokeand animal welfare. It provides a number of recommendations to minimise the level of severity in the most commonrodent models of middle cerebral artery occlusion, while sustaining or improving the scientific outcomes. The recommendationscover basic requirements pre-surgery, selecting the most appropriate anaesthetic and analgesic regimen, aswell as intraoperative and post-operative care. The aim is to provide support for researchers and animal care staff torefine their procedures and practices, and implement small incremental changes to improve the welfare of the animalsused and to answer the scientific question under investigation. All recommendations are recapitulated in a summaryposter (see supplementary information).

Item Type: Article
Authors/Creators:Percie du Sert, N and Alfieri, A and Allan, SM and Carswell, HV and Deuchar, GA and Farr, TD and Flecknell, P and Gallagher, L and Gibson, CL and Haley, MJ and Macleod, MR and McColl, BW and McCabe, C and Morancho, A and Moon, LD and O'Neill, MJ and Pe'rez de Puig, I and Planas, A and Ragan, CI and Rosell, A and Roy, LA and Ryder, KO and Simats, A and Sena, ES and Sutherland, BA and Tricklebank, MD and Trueman, RC and Whitfield, L and Wong, R and Macrae, IM
Keywords: improve, animal models, stroke, ischaemia, brain
Journal or Publication Title: Journal of Cerebral Blood Flow and Metabolism
Publisher: Lippincott Williams & Wilkins
ISSN: 0271-678X
DOI / ID Number: 10.1177/0271678X17709185
Copyright Information:

Copyright 2017 The AuthorsLicensed under Creative Commons Attribution 4.0 International (CC BY 4.0)https://creativecommons.org/licenses/by/4.0/

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