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TRPV1 channels in immune cells and hematological malignancies

Omari, SA, Adams, MJ and Geraghty, DP ORCID: 0000-0001-8968-5912 2017 , 'TRPV1 channels in immune cells and hematological malignancies', in DP Geraghty and LD Rash (eds.), Advances in Pharmacology/Ion Channel Pharmacology , Elsevier/Academic Press, Kansas City, pp. 173-198.

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Abstract

Transient receptor potential vanilloid-1 (TRPV1) is a member of the TRP family of channelsthat are responsible for nociceptive, thermal, and mechanical sensations. Originallyassociated exclusively with sensory neurons, TRPV1 is now known to be present inalmost all organs, including cells of the immune system, where TRPV1 has been shownto play a pivotal role in inflammation and immunity. Monocytes, macrophages, anddendritic cells express TRPV1, with both mouse and human studies suggesting thatTRPV1 activation protects against endotoxin-induced inflammation. In contrast, TRPV1(and other TRP channels) appears to be required for T-cell receptor activation bymitogens. Additionally, studies in cell lines derived from hematological and othermalignancies suggest altered expression/function of TRPV1 might serve as a target fornovel cytotoxic therapies.

Item Type: Book Section
Authors/Creators:Omari, SA and Adams, MJ and Geraghty, DP
Keywords: transient receptor potential vanilloid-1; vanilloid; capsaicin; hematological malignancy; cell death
Publisher: Elsevier/Academic Press
DOI / ID Number: 10.1016/bs.apha.2017.01.002
Copyright Information:

Copyright 2017 Elsevier Inc.

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