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Height, selected genetic markers and prostate cancer risk: results from the PRACTICAL consortium

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Lophatananon, A, Stewart-Brown, S, Kote-Jarai, Z, Olama, AAA, Garcia, SB, Neal, DE, Hamdy, FC, Donovan, JL, Giles, GG, Fitzgerald, LM ORCID: 0000-0002-6882-2698, Southey, MC, Pharoah, P, Pashayan, N, Gronberg, H, Wiklund, F, Aly, M, Stanford, JL, Brenner, H, Dieffenbach, AK, Arndt, V, Park, JY, Lin, HY, Sellers, T, Slavov, C, Kaneva, R, Mitev, V, Batra, J, Spurdle, A, Clements, JA, Easton, D, Eeles, RA and Muir, K 2017 , 'Height, selected genetic markers and prostate cancer risk: results from the PRACTICAL consortium' , British Journal of Cancer, vol. 117, no. 5 , pp. 734-743 , doi: 10.1038/bjc.2017.231.

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Abstract

Background: Evidence on height and prostate cancer risk is mixed, however, recent studies with large data sets support a possible role for its association with the risk of aggressive prostate cancer.Methods: We analysed data from the PRACTICAL consortium consisting of 6207 prostate cancer cases and 6016 controls and a subset of high grade cases (2480 cases). We explored height, polymorphisms in genes related to growth processes as main effects and their possible interactions.Results: The results suggest that height is associated with high-grade prostate cancer risk. Men with height >180 cm are at a 22% increased risk as compared to men with height Conclusions: There was no evidence of gene-environment interaction between height and the selected candidate SNPs. Our findings suggest a role of height in high-grade prostate cancer. The effect of genetic variants in the genes related to growth is seen in all cases and high-grade prostate cancer. There is no interaction between these two exposures.

Item Type: Article
Authors/Creators:Lophatananon, A and Stewart-Brown, S and Kote-Jarai, Z and Olama, AAA and Garcia, SB and Neal, DE and Hamdy, FC and Donovan, JL and Giles, GG and Fitzgerald, LM and Southey, MC and Pharoah, P and Pashayan, N and Gronberg, H and Wiklund, F and Aly, M and Stanford, JL and Brenner, H and Dieffenbach, AK and Arndt, V and Park, JY and Lin, HY and Sellers, T and Slavov, C and Kaneva, R and Mitev, V and Batra, J and Spurdle, A and Clements, JA and Easton, D and Eeles, RA and Muir, K
Keywords: height, SNPs, gene and environment interaction, prostate cancer
Journal or Publication Title: British Journal of Cancer
Publisher: Nature Publishing Group
ISSN: 0007-0920
DOI / ID Number: 10.1038/bjc.2017.231
Copyright Information:

Copyright The Author(s). Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) http://creativecommons.org/licenses/by/4.0/

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