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Interplay of the quality of ciprofloxacin and antibiotic resistance in developing countries


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Sharma, D, Patel, RP ORCID: 0000-0001-9344-1013, Zaidi, STR ORCID: 0000-0002-2031-1055, Sarker, MMR, Lean, QY and Ming, LC ORCID: 0000-0002-6971-1383 2017 , 'Interplay of the quality of ciprofloxacin and antibiotic resistance in developing countries' , Frontiers in Pharmacology, vol. 8 , pp. 1-7 , doi: 10.3389/fphar.2017.00546.

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Ciprofloxacin, a second generation broad spectrum fluoroquinolone, is active against both Gram-positive and Gram-negative bacteria. Ciprofloxacin has a high oral bioavailability and a large volume of distribution. It is used for the treatment of a wide range of infections including urinary tract infections caused by susceptible bacteria. However, the availability and use of substandard and spurious quality of oral ciprofloxacin formulations in the developing countries has been thought to have contributed toward increased risk of treatment failure and bacterial resistance. Therefore, quality control and bioequivalence studies of the commercially available oral ciprofloxacin formulations should be monitored. Appropriate actions should be taken against offending manufacturers in order to prevent the sale of substandard and spurious quality of ciprofloxacin formulations.

Item Type: Article
Authors/Creators:Sharma, D and Patel, RP and Zaidi, STR and Sarker, MMR and Lean, QY and Ming, LC
Keywords: Ciprofloxacin, Quality, Resistance, Antimicrobials
Journal or Publication Title: Frontiers in Pharmacology
Publisher: Frontiers Research Foundation
ISSN: 1663-9812
DOI / ID Number: 10.3389/fphar.2017.00546
Copyright Information:

Copyright 2017 The Author(s)Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0)

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