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The independent effects of vitamin D deficiency and house dust mite exposure on lung function are sex-specific

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Nunez, NK, Bennett, E, Chen, L ORCID: 0000-0003-1897-9264, Pitrez, PM and Zosky, GR ORCID: 0000-0001-9039-0302 2017 , 'The independent effects of vitamin D deficiency and house dust mite exposure on lung function are sex-specific' , Scientific Reports, vol. 7 , pp. 1-8 , doi: 10.1038/s41598-017-15517-z.

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Official URL: http://dx.doi.org/

Abstract

Vitamin D defciency is increasing around the world and has been associated with the development ofasthma. This study aims to evaluate the efect of dietary vitamin D defciency at diferent life stageson lung function using a murine model of allergic airways disease. BALB/c mice were challengedintranasally with HDM or saline alone for 10 days. Twenty four hours after the last challenge, mice wereanesthetized and lung function was measured using the forced oscillation technique (FOT). Mice wereeuthanized for assessment of infammation in the bronchoalveolar lavage (BAL) and total collagencontent in lung homogenates by ELISA. Vitamin D defciency impaired lung function in both maleand female mice, increasing tissue damping and elastance, however had no efect on HDM inducedinfammation. The impact of vitamin D defciency was more evident in females. HDM also decreasedairway distensibility, but only in females and this response was not altered by vitamin D defciency. Ourdata suggest that vitamin D defciency and HDM exposure have independent efects on lung mechanicsand that females are more susceptible to these efects. Vitamin D defciency may exacerbate lungfunction defcits by having a direct, but independent, efect on parenchymal mechanics.

Item Type: Article
Authors/Creators:Nunez, NK and Bennett, E and Chen, L and Pitrez, PM and Zosky, GR
Keywords: vitamin D, house dust mite, asthma, lung function
Journal or Publication Title: Scientific Reports
Publisher: Nature Publishing Group
ISSN: 2045-2322
DOI / ID Number: 10.1038/s41598-017-15517-z
Copyright Information:

© The Author(s) 2017. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/

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