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STROKOG (stroke and cognition consortium): An international consortium to examine the epidemiology, diagnosis, and treatment of neurocognitive disorders in relation to cerebrovascular disease

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Sachdev, PS, Lo, JW, Crawford, JD, Mellon, L, Hickey, A, Williams, D, Bordet, R, Mendyk, AM, Gele, P, Deplanque, D, Bae, HJ, Lim, JS, Brodtmann, A, Werden, E, Cumming, T, Kohler, S, Verhey, FRJ, Dong, YH, Tan, HH, Chen, C, Xin, X, Kalaria, RN, Allan, LM, Akinyemi, RO, Ogunniyi, A, Klimkowicz-Mrowiec, A, Dichgans, M, Wollenweber, FA, Zietemann, V, Hoffmann, M, Desmond, DW, Linden, T, Blomstrand, C, Fagerberg, B, Skoog, I, Godefroy, O, Barbay, M, Roussel, M, Lee, BC, Yu, KH, Wardlaw, J, Makin, SJ, Doubal, FN, Chappell, FM, Srikanth, VK, Thrift, AG, Donnan, GA, Kandiah, N, Chander, RJ, Lin, X, Cordonnier, C, Moulin, S, Rossi, C, Sabayan, B, Stott, DJ, Jukema, JW, Melkas, S, Jokinen, H, Erkinjuntti, T, Mok, VCT, Wong, A, Lam, BY, Leys, D, Henon, H, Bombois, S, Lipnicki, DM and Kochan, NA 2017 , 'STROKOG (stroke and cognition consortium): An international consortium to examine the epidemiology, diagnosis, and treatment of neurocognitive disorders in relation to cerebrovascular disease' , Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, vol. 7 , pp. 11-23 , doi: 10.1016/j.dadm.2016.10.006.

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Abstract

Introduction: The Stroke and Cognition consortium (STROKOG) aims to facilitate a better understanding of the determinants of vascular contributions to cognitive disorders and help improve the diagnosis and treatment of vascular cognitive disorders (VCD).Methods: Longitudinal studies with ≥75 participants who had suffered or were at risk of stroke or TIA and which evaluated cognitive function were invited to join STROKOG. The consortium will facilitate projects investigating rates and patterns of cognitive decline, risk factors for VCD, and biomarkers of vascular dementia.Results: Currently, STROKOG includes 25 (21 published) studies, with 12,092 participants from five continents. The duration of follow-up ranges from 3 months to 21 years.Discussion: Although data harmonization will be a key challenge, STROKOG is in a unique position to reuse and combine international cohort data and fully explore patient level characteristics and outcomes. STROKOG could potentially transform our understanding of VCD and have a worldwide impact on promoting better vascular cognitive outcomes.

Item Type: Article
Authors/Creators:Sachdev, PS and Lo, JW and Crawford, JD and Mellon, L and Hickey, A and Williams, D and Bordet, R and Mendyk, AM and Gele, P and Deplanque, D and Bae, HJ and Lim, JS and Brodtmann, A and Werden, E and Cumming, T and Kohler, S and Verhey, FRJ and Dong, YH and Tan, HH and Chen, C and Xin, X and Kalaria, RN and Allan, LM and Akinyemi, RO and Ogunniyi, A and Klimkowicz-Mrowiec, A and Dichgans, M and Wollenweber, FA and Zietemann, V and Hoffmann, M and Desmond, DW and Linden, T and Blomstrand, C and Fagerberg, B and Skoog, I and Godefroy, O and Barbay, M and Roussel, M and Lee, BC and Yu, KH and Wardlaw, J and Makin, SJ and Doubal, FN and Chappell, FM and Srikanth, VK and Thrift, AG and Donnan, GA and Kandiah, N and Chander, RJ and Lin, X and Cordonnier, C and Moulin, S and Rossi, C and Sabayan, B and Stott, DJ and Jukema, JW and Melkas, S and Jokinen, H and Erkinjuntti, T and Mok, VCT and Wong, A and Lam, BY and Leys, D and Henon, H and Bombois, S and Lipnicki, DM and Kochan, NA
Keywords: cohort studies, data harmonization, international consortium, post-stroke dementia, small vessel disease, vascular cognitive disorder, vascular dementia
Journal or Publication Title: Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
Publisher: Elsevier Inc.
ISSN: 2352-8729
DOI / ID Number: 10.1016/j.dadm.2016.10.006
Copyright Information:

© 2016 The Authors. Licensed under Creative Commons CC BY-NC-ND license (http://creativecornrnons.org/licenses/by-nc-nd/4. 0/).

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