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Physical and chemical stability of ceftaroline in an elastomeric infusion device

Al Madfai, F, Razi Zaidi, ST ORCID: 0000-0002-2031-1055, Ming, LC ORCID: 0000-0002-6971-1383, Wanandy, T ORCID: 0000-0003-4703-0488 and Patel, RP ORCID: 0000-0001-9344-1013 2017 , 'Physical and chemical stability of ceftaroline in an elastomeric infusion device' , European Journal of Hospital Pharmacy , pp. 1-5 , doi: 10.1136/ejhpharm-2017-001221.

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Abstract

Background: Severe infections such as endocarditisand osteomyelitis require long-term treatmentwith parenteral antibiotics and hence prolongedhospitalisation. Continuous infusion of ceftarolinethrough elastomeric devices can facilitate early hospitaldischarge by managing parenteral antibiotics in patient'shome. Therefore, the purpose of this study was toinvestigate the stability of ceftaroline in a commonlyused elastomeric device.Method: A total of 24 elastomeric devices wereprepared, and six elastomeric devices containing 6mg/mL of ceftaroline (three in each type of diluents) werestored at one of the following conditions: 4°C for 6days, 25°C for 24hours, 30°C for 24hours or 35°C for24hours. An aliquot was withdrawn before storage andat different time points. Chemical stability was measuredusing a stability indicating high-performance liquidchromatography, and physical stability was assessed aschange in pH, colour and particle content.Results: Ceftaroline, when admixed with both diluents,was stable for 144, 24 and 12hours at 4°C, 25°C and30°C, respectively. At 35°C, ceftaroline admixed withnormal saline (NS) and glucose 5% was stable for12hours and for 6hours, respectively. No evidence ofparticle formation, colour change or pH change wasobserved throughout the study period.Conclusions: Our findings support 12 or 24hourscontinuous elastomeric infusion of ceftaroline-NSadmixture, and bulk preparation of elastomeric pumpscontaining ceftaroline solution in advance. This wouldfacilitate early hospital discharge of patients eligible forthe elastomeric-based home therapy and avoid the needfor patient's caregivers travelling to the hospital on adaily basis.

Item Type: Article
Authors/Creators:Al Madfai, F and Razi Zaidi, ST and Ming, LC and Wanandy, T and Patel, RP
Keywords: chromatography, ceftaroline, stability, elastomeric devices, infusion
Journal or Publication Title: European Journal of Hospital Pharmacy
Publisher: B M J Group
ISSN: 2047-9964
DOI / ID Number: 10.1136/ejhpharm-2017-001221
Copyright Information:

© European Association of Hospital Pharmacists (unless otherwise stated in thetext of the article) 2017

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