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Traffic-related air pollution exposure over a 5-year period is associated with increased risk of asthma and poor lung function in middle age

Bowatte, G, Erbas, B, Lodge, CJ, Knibbs, LD, Gurrin, LC, Marks, GB, Thomas, PS, Johns, DP ORCID: 0000-0002-1575-6850, Giles, GG, Hui, J, Dennekamp, M, Perret, JL, Abramson, MJ, Walters, EH, Matheson, MC and Dharmage, SC 2017 , 'Traffic-related air pollution exposure over a 5-year period is associated with increased risk of asthma and poor lung function in middle age' , European Respiratory Journal, vol. 50, no. 4 , doi: 10.1183/13993003.02357-2016.

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Abstract

Current evidence concerning the impact of exposure to traffic-related air pollution (TRAP) on adult respiratory morbidity mainly comes from cross-sectional studies. We sought to establish more robust measures of this association and potential gene-environment interactions using longitudinal data from an established cohort study.Associations between measures of TRAP (nitrogen dioxide (NO2) and distance to major roads) and wheeze, asthma prevalence and lung function were investigated in participants of the Tasmanian Longitudinal Health Study at 45- and 50-year follow-ups. Generalised estimating equations were used to quantify associations and the potential modifying effect of glutathione S-transferase gene variants.Living 2 exposures were associated with increased current asthma prevalence. Higher NO2 exposure was associated with lower forced vital capacity for carriers of the GSTT1 null genotype.TRAP exposures were associated with increased risk of asthma, wheeze and lower lung function in middle-aged adults. The interaction with the GSTT1 genotype suggests that deficient antioxidant mechanisms may play a role in these adverse health effects.

Item Type: Article
Authors/Creators:Bowatte, G and Erbas, B and Lodge, CJ and Knibbs, LD and Gurrin, LC and Marks, GB and Thomas, PS and Johns, DP and Giles, GG and Hui, J and Dennekamp, M and Perret, JL and Abramson, MJ and Walters, EH and Matheson, MC and Dharmage, SC
Keywords: lung function, traffic-related pollution, asthma
Journal or Publication Title: European Respiratory Journal
Publisher: European Respiratory Society
ISSN: 0903-1936
DOI / ID Number: 10.1183/13993003.02357-2016
Copyright Information:

Copyright © ERS 2017

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