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Epithelial and endothelial cell plasticity in chronic obstructive pulmonary disease (COPD)

Sohal, SS ORCID: 0000-0001-9627-6498 2017 , 'Epithelial and endothelial cell plasticity in chronic obstructive pulmonary disease (COPD)' , Respiratory investigation, vol. 55, no. 2 , pp. 104-113 , doi: 10.1016/j.resinv.2016.11.006.

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Abstract

Chronic Obstructive Pulmonary Disease (COPD) is mainly caused by smoking and presents with shortness of breath that is progressive and irreversible. It is a worldwide health problem and the fourth most common cause of chronic disability and mortality (even in developed countries). It is a complex disease involving both the airway and lung parenchyma. Small-airway fibrosis is the main contributor to physiological airway dysfunction in COPD. One potential mechanism contributing to small-airway fibrosis is epithelial mesenchymal transition (EMT). When associated with angiogenesis (EMT-type-3), EMT may well also be linked to the development of airway epithelial cancer, which is closely associated with COPD and predominantly observed in large airways. Vascular remodeling has also been widely reported in smokers and patients with COPD but the mechanisms behind it are poorly understood. It is quite possible that the process of endothelial to mesenchymal transition (EndMT) is also active in COPD lungs, in addition to EMT. Understanding these pathological mechanisms will greatly enhance our knowledge of the immunopathology of smoking-related lung disease. Only by understanding these processes can new therapies be developed.

Item Type: Article
Authors/Creators:Sohal, SS
Keywords: COPD, ICS, inflammation, lung cancer, EMT
Journal or Publication Title: Respiratory investigation
Publisher: Elsevier
ISSN: 2212-5345
DOI / ID Number: 10.1016/j.resinv.2016.11.006
Copyright Information:

Copyright 2016 Crown Copyright

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