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Profiling cellular and inflammatory changes in the airway wall of mild to moderate COPD

Eapen, MS, McAlinden, K, Tan, D, Weston, S, Ward, C, Muller, HK, Walters, EH ORCID: 0000-0002-0993-4374 and Sohal, SS ORCID: 0000-0001-9627-6498 2017 , 'Profiling cellular and inflammatory changes in the airway wall of mild to moderate COPD' , Respirology, vol. 22, no. 6 , pp. 1125-1132 , doi: 10.1111/resp.13021.

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Abstract

Background and objective: The objective of this studywas to enumerate total cells and the number of inflammatorycell differentials in large airways (LAs) versussmall airways (SAs) of mild-moderate COPD, andagainst appropriate controls.Methods: For LA, we used endobronchial biopsies andfor SA resected lung tissues. Immunostaining wasenumerated (cells per mm2) for macrophages, neutrophils,CD4 and CD8 T cells in the lamina propria (LP)up to 150 μM deep for LA and full wall thickness for SA.Results: We confirmed hypocellularity in the LA and inthe SA wall in smokers and COPD (P P P P P P Conclusion: These unique data indicate that the currentmodel for airway wall inflammation in COPD is oversimplified,and contrast with innate inflammatory activationin the lumen, at least in mild-moderate disease.Any abnormalities in airway wall cell differentials aresmall, although exaggerated in percentage terms.

Item Type: Article
Authors/Creators:Eapen, MS and McAlinden, K and Tan, D and Weston, S and Ward, C and Muller, HK and Walters, EH and Sohal, SS
Keywords: COPD, ICS, inflammation, lung cancer, EMT
Journal or Publication Title: Respirology
Publisher: Blackwell Publishing Asia
ISSN: 1323-7799
DOI / ID Number: 10.1111/resp.13021
Copyright Information:

Copyright 2017 Asian Pacific Society of Respirology

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