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Pain and antisepsis after ocular administration of povidone-iodine versus chlorhexidine

Oakley, C, Allen, PL ORCID: 0000-0003-1945-8049, Hooshmand, J and Vote, B 2017 , 'Pain and antisepsis after ocular administration of povidone-iodine versus chlorhexidine' , Retina: The Journal of Retinal and Vitreous Diseases , pp. 1-3 , doi: 10.1097/IAE.0000000000001800.

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Purpose:To investigate ocular bacterial count before and after antisepsis withaqueous chlorhexidine (AC) or povidone-iodine (PI) and to assess discomfort with eachagent.Methods:Bacterial swabs were taken from participants’ eyes before and after antisepsis.These underwent microscopy, culture, and sensitivity testing. Aqueous chlorhexidinedrops were administered to left eyes and PI to right eyes. Participants rated their pain (scale0–10) for each eye but were blinded to the type of drop.Results:There were 20 participants (17 women, 3 men), and the mean age was 43 years.Pain scores were significantly higher in right (PI) than in left (AC) eyes (mean 7 vs. mean 2,P , 0.001). No abnormalities were detected on specimen microscopy and gram staining.Seven preantisepsis swabs (three left and four right) grew bacteria in culture. Two postantisepsis swabs grew bacteria in primary culture plate (1 after AC and 1 after PI). For anadditional one post-PI swab, bacteria were detected in enrichment broth only.Conclusion: The efficacy of AC and PI are similar, and patient discomfort is lower with AC. Aqueous chlorhexidine is a good alternative to PI for antisepsis before intravitreal injection.

Item Type: Article
Authors/Creators:Oakley, C and Allen, PL and Hooshmand, J and Vote, B
Keywords: povidone iodine, chlorhexidine, antisepsis, intravitreal injections
Journal or Publication Title: Retina: The Journal of Retinal and Vitreous Diseases
Publisher: Lippincott Williams & Wilkins
ISSN: 0275-004X
DOI / ID Number: 10.1097/IAE.0000000000001800
Copyright Information:

Copyright 2017 Ophthalmic Communications Society, Inc.

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