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How do MRI-detected subchondral bone marrow lesions (BMLs) on two different MRI sequences correlate with clinically important outcomes?
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ORCID: 0000-0001-5685-7634, Wills, K ORCID: 0000-0003-3897-2908, Laslett, L ORCID: 0000-0002-4336-0095, Ding, C ORCID: 0000-0002-9479-730X, Pelletier, J-P, Martel-Pelletier, J, Graves, SE, Lorimer, M, Cicuttini, F and Jones, G ORCID: 0000-0002-9814-0006 2018
, 'How do MRI-detected subchondral bone marrow lesions (BMLs) on two different MRI sequences correlate with clinically important outcomes?'
, Calcified Tissue International
, pp. 1-13
, doi: 10.1007/s00223-018-0402-8.
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Abstract
The aim of this study is to describe the association of bone marrow lesions (BMLs) present on two different MRI sequences with clinical outcomes, cartilage defect progression, cartilage volume loss over 2.7 years, and total knee replacement (TKR) over 13.3 years. 394 participants (50-80 years) were assessed at baseline and 2.7 years. BML presence at baseline was scored on T1-weighted fat-suppressed 3D gradient-recalled acquisition (T1) and T2-weighted fat-suppressed 2D fast spin-echo (T2) sequences. Knee pain, function, and stiffness were assessed using WOMAC. Cartilage volume and defects were assessed using validated methods. Incident TKR was determined by data linkage. BMLs were mostly present on both MRI sequences (86%). BMLs present on T2, T1, and both sequences were associated with greater knee pain and functional limitation (odds ratio = 1.49 to 1.70; all p p p p p < 0.05). BMLs present on T2, T1, and both sequences were strongly associated with incident TKR. BMLs can be assessed on either T2- or T1-weighted sequences with no clinical predictive advantage of either sequence.
| Item Type: | Article |
|---|---|
| Authors/Creators: | Mattap, SM and Aitken, D and Wills, K and Laslett, L and Ding, C and Pelletier, J-P and Martel-Pelletier, J and Graves, SE and Lorimer, M and Cicuttini, F and Jones, G |
| Keywords: | bone marrow lesions, cartilage, MRI osteoarthritis, pain |
| Journal or Publication Title: | Calcified Tissue International |
| Publisher: | Springer-Verlag |
| ISSN: | 0171-967X |
| DOI / ID Number: | 10.1007/s00223-018-0402-8 |
| Copyright Information: | © Springer Science+Business Media, LLC, part of Springer Nature 2018 |
| Related URLs: | |
| Item Statistics: | View statistics for this item |
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