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Low intensity repetitive transcranial magnetic stimulation modulates skilled motor learning in adult mice

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Tang, AD, Bennett, W ORCID: 0000-0002-1559-3027, Hadrill, C, Collins, J, Fulopova, B, Wills, K ORCID: 0000-0003-3897-2908, Bindoff, A ORCID: 0000-0002-0943-2702, Puri, R ORCID: 0000-0002-0231-1369, Garry, MI ORCID: 0000-0002-5113-0986, Hinder, MR ORCID: 0000-0002-5240-4790, Summers, JJ, Rodger, J and Canty, AJ ORCID: 0000-0001-5165-2365 2018 , 'Low intensity repetitive transcranial magnetic stimulation modulates skilled motor learning in adult mice' , Scientific Reports, vol. 8 , pp. 1-9 , doi: 10.1038/s41598-018-22385-8.

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Abstract

Repetitive transcranial magnetic stimulation (rTMS) is commonly used to modulate cortical plasticity in clinical and non-clinical populations. Clinically, rTMS is delivered to targeted regions of the cortex at high intensities (>1 T). We have previously shown that even at low intensities, rTMS induces structural and molecular plasticity in the rodent cortex. To determine whether low intensity rTMS (LI-rTMS) alters behavioural performance, daily intermittent theta burst LI-rTMS (120 mT) or sham was delivered as a priming or consolidating stimulus to mice completing 10 consecutive days of skilled reaching training. Relative to sham, priming LI-rTMS (before each training session), increased skill accuracy (~9%) but did not alter the rate of learning over time. In contrast, consolidating LI-rTMS (after each training session), resulted in a small increase in the rate of learning (an additional ~1.6% each day) but did not alter the daily skill accuracy. Changes in behaviour with LI-rTMS were not accompanied with long lasting changes in brain-derived neurotrophic factor (BDNF) expression or in the expression of plasticity markers at excitatory and inhibitory synapses for either priming or consolidation groups. These results suggest that LI-rTMS can alter specific aspects of skilled motor learning in a manner dependent on the timing of intervention.

Item Type: Article
Authors/Creators:Tang, AD and Bennett, W and Hadrill, C and Collins, J and Fulopova, B and Wills, K and Bindoff, A and Puri, R and Garry, MI and Hinder, MR and Summers, JJ and Rodger, J and Canty, AJ
Keywords: transcranial magnetic stimulation, non-invasive brain stimulation, theta burst stimulation
Journal or Publication Title: Scientific Reports
Publisher: Nature Publishing Group
ISSN: 2045-2322
DOI / ID Number: 10.1038/s41598-018-22385-8
Copyright Information:

Copyright 2018 The Authors. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/

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