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Environmental and genetic determinants of two Vitamin D metabolites in healthy Australian children


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Bima, A, Pezic, A, Sun, C, Cameron, FJ, Rodda, C, van der Mei, I ORCID: 0000-0001-9009-7472, Chiaroni-Clarke, R, Dwyer, T, Kemp, A, Qu, J, Carlin, J, Ellis, JA and Ponsonby, AL 2017 , 'Environmental and genetic determinants of two Vitamin D metabolites in healthy Australian children' , Journal of Pediatric Endocrinology and Metabolism, vol. 30, no. 5 , pp. 531-541 , doi: 10.1515/jpem-2016-0088.

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Background: Vitamin D deficiency has been associated with adverse health outcomes. We examined genetic and environmental determinants of serum 25(OH)D3 and 1,25(OH)2D3 in childhood.Methods: The study sample consisted of 322 healthy Australian children (predominantly Caucasians) who provided a venous blood sample. A parental interview was conducted and skin phototype and anthropometry measures were assessed. Concentrations of 25(OH)D3 and 1,25(OH)2D3 were measured by selective solid-phase extraction-capillary liquid chromatography-tandem mass spectrometry. These concentrations were deseasonalised where relevant to remove the effect of month of sampling.Results: Deseasonalised log 25(OH)D3 and 1,25(OH)2D3 concentrations were only moderately correlated (r=0.42, pConclusions: Environmental factors and genetic factors contributed to both vitamin D metabolite concentrations. The intriguing finding that the higher ambient UVR contributed to higher 1,25(OH)2D3 after accounting for 25(OH)D3 concentrations requires further evaluation.

Item Type: Article
Authors/Creators:Bima, A and Pezic, A and Sun, C and Cameron, FJ and Rodda, C and van der Mei, I and Chiaroni-Clarke, R and Dwyer, T and Kemp, A and Qu, J and Carlin, J and Ellis, JA and Ponsonby, AL
Keywords: 1,25-dihydroxyvitamin D3, allelic score, determinants, ultraviolet radiation, vitamin D 25-hydroxyvitamin D3
Journal or Publication Title: Journal of Pediatric Endocrinology and Metabolism
Publisher: Freund Publishing House Ltd
ISSN: 0334-018X
DOI / ID Number: 10.1515/jpem-2016-0088
Copyright Information:

© 2017 Walter de Gruyter

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